The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.yexcr.2008.12.023 (literal)

Alternative label

• Serafino A.1; Balestrieri E.2; Pierimarchi P.1; Matteucci C.2; Moroni G.2; Oricchio E.2,4; Rasi G.1; Mastino A.3; Spadafora C.4; Garaci E.2; Sinibaldi Vallebona P.2 (2009)
  The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation
  in Experimental cell research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Serafino A.1; Balestrieri E.2; Pierimarchi P.1; Matteucci C.2; Moroni G.2; Oricchio E.2,4; Rasi G.1; Mastino A.3; Spadafora C.4; Garaci E.2; Sinibaldi Vallebona P.2 (literal)

Pagina inizio

• 849 (literal)

Pagina fine

• 862 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact factor = 3,777 - Epub 2009 Jan 8. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 315 (literal)

Rivista

• Experimental cell research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 = CNR Institute of Neurobiology and Molecular Medicine, Research Area of Tor Vergata,Rome, Italy; 2 = Department of Experimental Medicine and Biochemical Science -University of Rome, Tor Vergata, Rome, Italy; 3 = Department of Life Sciences, University of Messina, Messina, Italy; 4 = National Institute of Health, Rome, Italy (literal)

Titolo

• The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation (literal)

Abstract

• Melanoma development is a multi-step process arising from a series of genetic and epigenetic events. Although the sequential stages involved in progression from melanocytes to malignant melanoma are clearly defined, our current understanding of the mechanisms leading to melanoma onset is still incomplete. Growing evidence show that the activation of endogenous retroviral sequences might be involved in transformation of melanocytes as well as in the increased ability of melanoma cells to escape immune surveillance. Here we show that human melanoma cells in vitro undergo a transition from adherent to a more malignant, non-adherent phenotype when exposed to stress conditions. Melanoma-derived non-adherent cells are characterized by an increased proliferative potential and a decreased expression of both HLA class I molecules and Melan-A/MART-1 antigen, similarly to highly malignant cells. These phenotypic and functional modifications are accompanied by the activation of human endogenous retrovirus K expression (HERV-K) and massive production of viral-like particles. Down-regulation of HERV-K expression by RNA interference prevents the transition from the adherent to the non-adherent growth phenotype in low serum. These results implicate HERV-K in at least some critical steps of melanoma progression. (literal)

Prodotto di

• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)
• Patologie infettive, infiammatorie e degenerative (ME.P04.005.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• ANNALUCIA SERAFINO (Persona)
• GUIDO RASI (Unità di personale esterno)
• PASQUALE PIERIMARCHI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANNALUCIA SERAFINO (Persona)
• PASQUALE PIERIMARCHI (Unità di personale interno)
• GUIDO RASI (Unità di personale esterno)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Patologie infettive, infiammatorie e degenerative (ME.P04.005.001) (Modulo)
• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Experimental cell research (Rivista)

Insieme di parole chiave di

• Parole chiave di "The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation" (Insieme di parole chiave)