http://www.cnr.it/ontology/cnr/individuo/prodotto/ID48584
Phagocytosis of Biocompatible Gold Nanoparticles (Articolo in rivista)
- Type
- Label
- Phagocytosis of Biocompatible Gold Nanoparticles (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1021/la102758f (literal)
- Alternative label
Krpetic, Zeljika; Porta, Francesca; Caneva, Enrico; Dal Santo, Vladimiro; Scarì, Giorgio (2010)
Phagocytosis of Biocompatible Gold Nanoparticles
in Langmuir; ACS, American chemical society, Washington, DC (Stati Uniti d'America)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Krpetic, Zeljika; Porta, Francesca; Caneva, Enrico; Dal Santo, Vladimiro; Scarì, Giorgio (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- DOI: 10.1021/la102758f (literal)
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- Scopu (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Chimica Inorganica Metallorganica e Analitica \"Lamberto Malatesta\", University of Milan, Via Venezian 21, 20133 Milan, Italy
Centro Interdipartimentale Grandi Apparecchiature (C.I.G.A.), Via Golgi 19, 20133 Milan, Italy
CNR-Istituto di Scienze e Tecnologie Molecolari, Via Golgi, 19, Milano I-20133, Italy
Dipartimento di Biologia 7b, University of Milan, Via Celoria 26, 20133 Milan, Italy (literal)
- Titolo
- Phagocytosis of Biocompatible Gold Nanoparticles (literal)
- Abstract
- We report the evidence for the cellular uptake of gold nanoparticles via the phagocytosis mechanism in murine macrophage cells strongly supported by TEM and optical microscopy. Nanoparticles were prepared using
several biocompatible molecules of choice (5-aminovaleric acid, L-DOPA, melatonin, and serotonin hydrochloride) as stabilizers for gold colloids. Their surface chemistry was fully characterized by UV-vis, ATR-FTIR, 1H NMR, and HR-MAS 1H NMR spectroscopies, and size distribution was determined by CPS disc centrifuge and TEM. Differences in coatings were evaluated against cellular uptake, and a preferential movement of macrophages toward 5-aminovaleric acid-modified gold nanoparticles was shown, leading to the fast accumulation of nanoparticles in the cytosol. (literal)
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