Towards a universal methods for the stable and clean functionalization of inert perfluoropolymer nanoparticles: exploiting photopolymerizable amphiphilic diacetylenes (Articolo in rivista)

Type
Label
  • Towards a universal methods for the stable and clean functionalization of inert perfluoropolymer nanoparticles: exploiting photopolymerizable amphiphilic diacetylenes (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/adfm.201001274 (literal)
Alternative label
  • Morasso, C.; Colombo, M.; Ronchi, S.; Polito, L.; Mazzuchelli, S.; Monti, D.; Buscaglia, M.; Bellini, T; Prosperi, D. (2010)
    Towards a universal methods for the stable and clean functionalization of inert perfluoropolymer nanoparticles: exploiting photopolymerizable amphiphilic diacetylenes
    in Advanced functional materials (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Morasso, C.; Colombo, M.; Ronchi, S.; Polito, L.; Mazzuchelli, S.; Monti, D.; Buscaglia, M.; Bellini, T; Prosperi, D. (literal)
Pagina inizio
  • 3932 (literal)
Pagina fine
  • 3940 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://dx.doi.org/10.1002/adfm.201001274 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 20 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • DOI: 10.1002/adfm.201001274 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • [M. Colombo, S. Mazzucchelli, D. Prosperi] Dipartimento di Biotecnologie e Bioscienze Università degli Studi di Milano-Bicocca Piazza della Scienza 2, 20126 Milan (Italy) and CMENA Università degli Studi di Milano, Via G.B. Grassi 74, 20157 Milano (Italy) [C. Morasso, S. Ronchi, L. Polito, D. Monti, D. Prosperi] Istituto di Scienze e Tecnologie Molecolari CNR, via Fantoli 16/15, 20138 Milano (Italy) [M. Buscaglia, T. Bellini] Dipartimento di Chimica, Biochimica e Biotecnologie per la Medicina Università degli Studi di Milano Via F.lli Cervi 93, 20090 Segrate (Italy) (literal)
Titolo
  • Towards a universal methods for the stable and clean functionalization of inert perfluoropolymer nanoparticles: exploiting photopolymerizable amphiphilic diacetylenes (literal)
Abstract
  • Highly fl uorinated materials are being widely investigated due to a number of peculiar properties, which are potentially useful for various applications, including use as lubricants, anti-adhesive fi lms, and substitutes for biological fl uids for biomedical utilization. However, at present such potential is still poorly exploited. One of the major drawbacks that hampers the rapid development of nanoscale fluoro-hybrid devices is the remarkable inertness of perfluoropolymeric materials that lack reactive functionalities, as they do not offer any functional groups that can be employed to covalently anchor organic molecules on their surface. In this paper, a convenient method for the stable iofunctionalization of strongly unreactive perfl uoropolymer nanoparticles (PnPs) is reported. PnPs are easily coated with newly synthesized asymmetric diacetylenic monomer compounds (ADMs), thanks to PnP’s high propensity to interact with hydrophobic moieties. Once monomerically adsorbed onto PnPs, such suitably designed ADMs enable the formation of a robust polymeric shell around the perfl uoroelastomer core via a clean UV-promoted localized photopolymerization. Given the peculiar optical characteristics of PnPs, the coating of the particles can be monitored step by step using light scattering, which also allows estimation of the fraction of reacted monomers by competitive adsorption with smaller particles. The potential of this method for the biofunctionalization of PnPs is demonstrated with representative proteins and carbohydrates. Among them, the extension to avidin–biotin technology may broaden the scope and applicability of this strategy to potentially a large number of molecules of biomedical interest. (literal)
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