Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s11064-007-9353-6 (literal)

Alternative label

• Geloso M.C.1; Giannetti S.1; Cenciarelli C.2; Budoni M.2; Casalbore P.3; Maira G.2; Michetti F.1 (2007)
  Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration
  in Neurochemical research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Geloso M.C.1; Giannetti S.1; Cenciarelli C.2; Budoni M.2; Casalbore P.3; Maira G.2; Michetti F.1 (literal)

Pagina inizio

• 2054 (literal)

Pagina fine

• 2061 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 32 (literal)

Rivista

• Neurochemical research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 12 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Institute of Human Anatomy and Cell Bology, Università Cattolica del Sacro Cuore, Roma 2 Institute of Neurosurgery, Univesristà cattolica del sacro Cuore, Roma 3 Institute of Neurobiology and Molecular Medicine, CNR, Roma (literal)

Titolo

• Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration (literal)

Abstract

• The present study investigates the survival and fate of neural stem cells/progenitor cells (NSC/NPCs) homografted into the hippocampus of rats treated with trimethyltin (TMT), a potent neurotoxicant considered a useful tool to obtain a well characterized model of neurodegeneration, to evaluate their possible role in the reparative mechanisms that accompany neurodegenerative events. NSC/NPCs expressing eGFP by lentivirus-mediated infection were stereotaxically grafted into the hippocampus of TMT-treated animals and controls. Two weeks after transplantation surviving NSC/NPCs were detectable in 60% of TMT-treated animals and 30% of controls, while 30 days after transplantation only 40% of TMT-treated animals showed surviving grafted cells, which were undetectable in controls. At both times investigated, while grafted NSC/NPCs differentiated into neurons or astrocytes could be observed in addition to undifferentiated NSC/ NPCs, we did not find evidence of structural integration of grafted cells into the main site of hippocampal lesion leading to appreciable repair. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Patologie del S.N. e Fattori di Crescita (ME.P02.010.001) (Modulo)

Autore CNR

• PATRIZIA CASALBORE (Persona)
• CARLO CENCIARELLI (Persona)

Insieme di parole chiave

• Keywords of "Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• PATRIZIA CASALBORE (Persona)
• CARLO CENCIARELLI (Persona)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Patologie del S.N. e Fattori di Crescita (ME.P02.010.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neurochemical research (Rivista)

Insieme di parole chiave di

• Keywords of "Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration" (Insieme di parole chiave)