Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration (Articolo in rivista)

Type
Label
  • Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s11064-007-9353-6 (literal)
Alternative label
  • Geloso M.C.1; Giannetti S.1; Cenciarelli C.2; Budoni M.2; Casalbore P.3; Maira G.2; Michetti F.1 (2007)
    Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration
    in Neurochemical research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Geloso M.C.1; Giannetti S.1; Cenciarelli C.2; Budoni M.2; Casalbore P.3; Maira G.2; Michetti F.1 (literal)
Pagina inizio
  • 2054 (literal)
Pagina fine
  • 2061 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 32 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 12 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Institute of Human Anatomy and Cell Bology, Universit√† Cattolica del Sacro Cuore, Roma 2 Institute of Neurosurgery, Univesrist√† cattolica del sacro Cuore, Roma 3 Institute of Neurobiology and Molecular Medicine, CNR, Roma (literal)
Titolo
  • Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration (literal)
Abstract
  • The present study investigates the survival and fate of neural stem cells/progenitor cells (NSC/NPCs) homografted into the hippocampus of rats treated with trimethyltin (TMT), a potent neurotoxicant considered a useful tool to obtain a well characterized model of neurodegeneration, to evaluate their possible role in the reparative mechanisms that accompany neurodegenerative events. NSC/NPCs expressing eGFP by lentivirus-mediated infection were stereotaxically grafted into the hippocampus of TMT-treated animals and controls. Two weeks after transplantation surviving NSC/NPCs were detectable in 60% of TMT-treated animals and 30% of controls, while 30 days after transplantation only 40% of TMT-treated animals showed surviving grafted cells, which were undetectable in controls. At both times investigated, while grafted NSC/NPCs differentiated into neurons or astrocytes could be observed in addition to undifferentiated NSC/ NPCs, we did not find evidence of structural integration of grafted cells into the main site of hippocampal lesion leading to appreciable repair. (literal)
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