http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4847
Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration (Articolo in rivista)
- Type
- Label
- Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s11064-007-9353-6 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Geloso M.C.1; Giannetti S.1; Cenciarelli C.2; Budoni M.2; Casalbore P.3; Maira G.2; Michetti F.1 (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1 Institute of Human Anatomy and Cell Bology, Università Cattolica del Sacro Cuore, Roma
2 Institute of Neurosurgery, Univesristà cattolica del sacro Cuore, Roma
3 Institute of Neurobiology and Molecular Medicine, CNR, Roma (literal)
- Titolo
- Transplantation of Foetal Neural Stem Cells into the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration (literal)
- Abstract
- The present study investigates the survival and
fate of neural stem cells/progenitor cells (NSC/NPCs) homografted
into the hippocampus of rats treated with trimethyltin
(TMT), a potent neurotoxicant considered a useful
tool to obtain a well characterized model of neurodegeneration,
to evaluate their possible role in the reparative
mechanisms that accompany neurodegenerative events.
NSC/NPCs expressing eGFP by lentivirus-mediated
infection were stereotaxically grafted into the hippocampus
of TMT-treated animals and controls. Two weeks after
transplantation surviving NSC/NPCs were detectable in
60% of TMT-treated animals and 30% of controls, while
30 days after transplantation only 40% of TMT-treated
animals showed surviving grafted cells, which were
undetectable in controls. At both times investigated, while
grafted NSC/NPCs differentiated into neurons or astrocytes
could be observed in addition to undifferentiated NSC/
NPCs, we did not find evidence of structural integration of
grafted cells into the main site of hippocampal lesion
leading to appreciable repair. (literal)
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