Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jinorgbio.2009.05.009 (literal)

Alternative label

• 1-Marzano, C.; 2-Sbovata, S.M.; 1-Gandin, V.; 2-Michelin, R.A.; 3-Venzo, A.; 2-Bertani, R.; 3-Seraglia, R. (2009)
  Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity
  in Journal of inorganic biochemistry; Elsevier Inc., San Diego (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• 1-Marzano, C.; 2-Sbovata, S.M.; 1-Gandin, V.; 2-Michelin, R.A.; 3-Venzo, A.; 2-Bertani, R.; 3-Seraglia, R. (literal)

Pagina inizio

• 1113 (literal)

Pagina fine

• 1119 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.elsevier.com/locate/jinorgbio (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 103 (literal)

Rivista

• Journal of inorganic biochemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• DOI: 10.1016/j.jinorgbio.2009.05.009 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1-Department of Pharmaceutical Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy 2-Department of Chemical Processes of Engineering, University of Padova, Via F. Marzolo 9, 35131 Padova, Italy 3-CNR-ISTM, Institute of Sciences and Molecular Technologies, Via F. Marzolo 1, 35131 Padova, Italy (literal)

Titolo

• Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity (literal)

Abstract

• A series of new platinum(11) amidine derivatives of the type cis-[PtCl2(Z-NH=C(NHR)Me}(2)] (R = cyclopropyl, 1; cyclopentyl, 2; cyclohexyl, 3) were prepared in high yield by addition of the corresponding cyclic aliphatic amine RNH2 to the coordinated acetonitrile ligands in cis-[PtCl2(NCMe)(2)]. The solution behaviour of 1-3 has been studied in DMSO, PEG 400 (polyethylene glycol) and PEG-DME 500 (polyethylene glycol dimethylether). The amidine complexes 1-3 were evaluated for their cytotoxic properties against a panel of human tumor cell lines containing examples of cervix (HeLa), breast (MCF7), lung (A549) and colon (HCT-15) cancer. Moreover, the amidine complexes were tested for their cytotoxicity against normal human fibroblasts (HFF-1). For comparison purposes, the cytotoxicity of cisplatin was examined under the same experimental conditions. The results obtained showed that PEG and PEG-DME behave as good solvents to carry out biological assays with platinum complexes which are water-insoluble and unstable in DMSO. Complexes 2 and 3 exhibited a biological activity comparable to that of cisplatin. (literal)

Editore

• Elsevier Inc. (Editore)

Prodotto di

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)

Autore CNR

• ROBERTA SERAGLIA (Persona)
• ALFONSO VENZO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)

Autore CNR di

• ROBERTA SERAGLIA (Persona)
• ALFONSO VENZO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of inorganic biochemistry (Rivista)

Editore di

• Elsevier Inc. (Editore)

Insieme di parole chiave di

• Keywords of "Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity" (Insieme di parole chiave)