Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands. Synthesis, Characterization, Structure-Activity Relationships, in Vitro and in Vivo Antitumor Efficacy (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands. Synthesis, Characterization, Structure-Activity Relationships, in Vitro and in Vivo Antitumor Efficacy (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/jm070426p (literal)

Alternative label

• S. Mazzega Sbovata;, F. Bettio; M. Mozzon; R. Bertani; A. Venzo; F. Benetollo; R. A. Michelin; V. Gandin; C. Marzano (2007)
  Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands. Synthesis, Characterization, Structure-Activity Relationships, in Vitro and in Vivo Antitumor Efficacy
  in Journal of medicinal chemistry; American Chemical Society, Washington (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• S. Mazzega Sbovata;, F. Bettio; M. Mozzon; R. Bertani; A. Venzo; F. Benetollo; R. A. Michelin; V. Gandin; C. Marzano (literal)

Pagina inizio

• 4775 (literal)

Pagina fine

• 4784 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• pubblicazione scientifica (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://pubs.acs.org/doi/abs/10.1021/jm070426p (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 50 (literal)

Rivista

• Journal of medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1,3,4,7 : Department of Chemical Processes of Engineering, Uni Versity of Pado Va, Via F. Marzolo 9, 35131 Padova, Italy 2,8,9 : Department of Pharmaceutical Sciences, UniVersity of Pado Va, Via F. Marzolo 5, 35131 Padova, Italy 5 : Institute of Sciences and Molecular Technologies, C.N.R., Via F. Marzolo 1, 35131 Padova, Italy 6 : ICIS-C.N.R., Corso Stati Uniti 4, 35127 PadoVa, Italy (literal)

Titolo

• Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands. Synthesis, Characterization, Structure-Activity Relationships, in Vitro and in Vivo Antitumor Efficacy (literal)

Abstract

• New benzyliminoether derivatives [PtCl2{N(H)dC(OMe)CH 2Ph}2] of cis(1a , 1b) and trans(2a , 2b) geometry were prepared and characterized by means of elemental analysis, multinuclear NMR and FT-IR techniques, and X-ray crystallography; this latter was carried out for 1b. The cytotoxic properties of these new platinum-(II) complexes were evaluated in terms of cell growth inhibition against a panel of different types of human cancer cell lines. cis-[PtCl2{E-N(H) dC(OMe)CH 2Ph}2](1a) was significantly more potent than cisplatin against all tumor cell lines tested, showing IC50 values from about 2- to 17-fold lower than the reference compound. Chemosensitivity tests performed on cisplatin-sensitive and -resistant cell lines have demonstrated that complex 1a is able to overcome cisplatin resistance. Analyzing the mechanism by which complex 1a led to cell death, we have found that it induced apoptosis in a dose-dependent manner, accompanied by the activation of caspase-3. The in vivo studies carried out using two transplantable tumor models (L1210 leukemia and Lewis lung carcinoma) showed that derivative1a induced a remarkable antitumor activity in both tumor models, as measured by prolonged survival and reduced tumor mass compared to control groups. (literal)

Editore

• American Chemical Society (Editore)

Prodotto di

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Progettazione molecolare di nanosistemi organizzati (PM.P05.007.001) (Modulo)

Autore CNR

• ALFONSO VENZO (Unità di personale interno)
• FRANCO BENETOLLO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands. Synthesis, Characterization, Structure-Activity Relationships, in Vitro and in Vivo Antitumor Efficacy" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Progettazione molecolare di nanosistemi organizzati (PM.P05.007.001) (Modulo)

Autore CNR di

• FRANCO BENETOLLO (Unità di personale interno)
• ALFONSO VENZO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of medicinal chemistry (Rivista)

Editore di

• American Chemical Society (Editore)

Insieme di parole chiave di

• Keywords of "Cisplatinum and Transplatinum Complexes with Benzyliminoether Ligands. Synthesis, Characterization, Structure-Activity Relationships, in Vitro and in Vivo Antitumor Efficacy" (Insieme di parole chiave)