http://www.cnr.it/ontology/cnr/individuo/prodotto/ID48075
Poly(amidoamine)s carrying TEMPO residues for NMR imaging applications (Articolo in rivista)
- Type
- Label
- Poly(amidoamine)s carrying TEMPO residues for NMR imaging applications (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1039/b712896g (literal)
- Alternative label
Gussoni, M.; Greco, F.; Ferruti, P.; Ranucci, E.; Ponti, A.; Zetta, L. (2008)
Poly(amidoamine)s carrying TEMPO residues for NMR imaging applications
in New journal of chemistry (1987)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Gussoni, M.; Greco, F.; Ferruti, P.; Ranucci, E.; Ponti, A.; Zetta, L. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Scienze e Tecnologie Biomediche, Universita` di
Milano, Via Fratelli Cervi, 93, I-20090 Segrate (MI), Italy. E-mail:
maristella.gussoni@unimi.it; Fax: (+39) 0250330414
Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle
Ricerche, Via E. Bassini, 15, I-20133 Milano, Italy. E-mail:
lucia.zetta@ismac.cnr.it; Fax: (+39) 0223699212
Dipartimento di Chimica Organica e Industriale, Universita` di
Milano, Via Venezian 21, I-20133 Milano, Italy
Istituto di Scienze e Tecnologie Molecolari, Consiglio Nazionale
delle Ricerche, Via Golgi 19, I-20133 Milano, Italy (literal)
- Titolo
- Poly(amidoamine)s carrying TEMPO residues for NMR imaging applications (literal)
- Abstract
- An amphoteric bio-compatible and stealth-like poly (amidoamine) named ISA23 was obtained
from 2,2-bis(acrylamido)acetic acid (BAC) and 2-methylpiperazine. The partial substitution of
4-amino-2,2,6,6-tetramethylpiperidin-1-oxyl (Amino-TEMPO) for 2-methylpiperazine as comonomer
gave two new PAA-TEMPO conjugates based on ISA23: ISA23-TEMPO1 and ISA23-
TEMPO2 with 10 and 40% TEMPO-carrying units per polymer chain, respectively. In this study,
a thorough NMR characterization of ISA23 polymer together with NMR and ESR
characterizations of the ISA23-TEMPO derivatives and a preliminary evaluation of their potential
as NMR labels for imaging applications are reported. Relaxivity measurements performed on
ISA23-TEMPO1 and ISA23-TEMPO2 showed relaxivities of 0.4 and 1.8 mM?1 s?1, respectively,
indicating that the PAA-TEMPO adducts have a definite potential as NMR imaging contrast
agents. This was confirmed by preliminary magnetic resonance imaging (MRI) determinations. (literal)
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- Autore CNR
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