Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells (Articolo in rivista)

Type
Label
  • Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Alternative label
  • Matrone C. ; Di Luzio A; Meli G.; D'Aguanno S.; Severini C.; Ciotti M.T.; Cattaneo A.; Calissano P. (2008)
    Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells
    in Journal of Alzheimer's disease
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Matrone C. ; Di Luzio A; Meli G.; D'Aguanno S.; Severini C.; Ciotti M.T.; Cattaneo A.; Calissano P. (literal)
Pagina inizio
  • 81 (literal)
Pagina fine
  • 96 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • IF (ISI WOS 2008) = 5.101 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://iospress.metapress.com/content/8m0w4q2485575h51/ (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 13 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Note
  • PubMe (literal)
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 - Institute of Neurobiology and Molecular Medicine, CNR, Via del Fosso di Fiorano, 64, 00143 Roma, Italy; 2 - EBRI (European Brain Research Institute), Via Fosso del Fiorano 64, Roma, Italy; 3 - IRCCS. Fondazione S. Lucia, Via del Fosso di Fiorano, 64, 00143 Roma, Italy; 4- Department of Medicina Interna, University of Rome \"Tor Vergata\", Via Montpellier, 1-00133 Roma, Italy; 5 - SISSA (International School for Advanced Studies), Via Beirut 2-4, 34013 Trieste, Italy (literal)
Titolo
  • Activation of the amyloidogenic route by NGF deprivation induces apoptotic death in PC12 cells (literal)
Abstract
  • Nerve growth factor (NGF) exerts a trophic, antiapoptotic action on several neuronal targets, including the clonal cell line PC12. In the current study, we demonstrate that withdrawal of this neurotrophin from PC12 differentiated cells causes overproduction of amyloid-beta (Abeta) peptides, which are the most toxic protein fragments directly implicated in the development of Alzheimer disease (AD), concomitantly with cell death by apoptosis. Abeta production and apoptotic death, occurring after withdrawal from NGF-differentiated PC12 cells, are completely inhibited by beta- and gamma-secretase inhibitors and by antibodies directed against Abeta peptides, favouring maintenance of PC12 morphology and neuritic network. These peptides are partially released and largely deposited as aggregates only soluble with strong detergent treatment generally employed to dissolve senile plaques. Furthermore, partial silencing of APP mRNA, by siRNA, reduces not only the extent of Abeta production but also apoptotic death. Abeta production and apoptosis are also induced in differentiated PC12 cells by kinase inhibitors of Trk-A, the high affinity receptor of NGF and, in this case, the co-incubation with beta- and gamma-secretase inhibitors totally revert apoptosis. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it