Progress in the Understanding of Drug-Receptor Interactions, Part 2: Experimental and Theoretical Electrostatic Moments and Interaction Energies of an Angiotensin II Receptor Antagonist (C30 H30 N6 O3 S) (Articolo in rivista)

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  • Progress in the Understanding of Drug-Receptor Interactions, Part 2: Experimental and Theoretical Electrostatic Moments and Interaction Energies of an Angiotensin II Receptor Antagonist (C30 H30 N6 O3 S) (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Alternative label
  • Soave R.; Barzaghi M.; Destro R. (2007)
    Progress in the Understanding of Drug-Receptor Interactions, Part 2: Experimental and Theoretical Electrostatic Moments and Interaction Energies of an Angiotensin II Receptor Antagonist (C30 H30 N6 O3 S)
    in Chemistry - A European Journal
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Soave R.; Barzaghi M.; Destro R. (literal)
Pagina inizio
  • 6942 (literal)
Pagina fine
  • 6956 (literal)
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  • 2006 ISI Impact Factor: 5.015 (literal)
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  • 13 (literal)
Rivista
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  • DOI:10.1002/chem.200601516 Supporting information for this article is available on the WWW under http://wiley-vch.de/contents/jc_2111/2007/f601516_s.pdf (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dr. R. Soave, Dr. M. Barzaghi: CNR-ISTM, Istituto di Scienze e Tecnologie Molecolari, Via C. Golgi 19, 20133 Milano, Italy. Prof. R. Destro: Dipartimento di Chimica Fisica ed Elettrochimica dell'Università degli Studi di Milano e CNR-ISTM, Via C. Golgi 19, 20133 Milano, Italy (literal)
Titolo
  • Progress in the Understanding of Drug-Receptor Interactions, Part 2: Experimental and Theoretical Electrostatic Moments and Interaction Energies of an Angiotensin II Receptor Antagonist (C30 H30 N6 O3 S) (literal)
Abstract
  • Drug-receptor interactions: A combined experimental and theoretical charge density study of an AT1 selective angiotensin II receptor antagonist named LR-B/081 is presented, focusing on electrostatic properties such as molecular electrostatic moments up to the fourth rank and the energies of intermolecular interactions. In this way, the key pharmacophoric features responsible for the high activity of LR-B/081 are elucidated and quantitatively characterised. (literal)
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