The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.phrs.2008.01.010 (literal)

Alternative label

• Aloe L. a), Tirassa P. a), Lambiase A. b) (2008)
  The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers
  in Pharmacological research (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Aloe L. a), Tirassa P. a), Lambiase A. b) (literal)

Pagina inizio

• 253 (literal)

Pagina fine

• 258 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Epub 2008 Feb 2. Review (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 57 (literal)

Rivista

• Pharmacological research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a) - Institute of Neurobiology and Molecular Medicine, NGF Section, National Research Council (CNR), 00413 Rome, Italy; b) - Ophthalmology, University of Rome “Campus Bio-Medico”, Rome, Italy. (literal)

Titolo

• The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers (literal)

Abstract

• AIM: The nerve growth factor is a soluble protein produced by and acting upon a number of different cells located in the nervous, endocrine and immune systems. Recent studies have shown that nerve growth factor (NGF) exerts a critical role on epithelial cells and fibroblasts under normal and pathological conditions. In this review, we present data prospecting the clinical potentiality of NGF in cutaneous and ocular \"non-healing\" chronic ulcers. DATA SYNTHESIS: A consistent number of in vitro and in vivo studies carried out on animal models and in humans indicated that fibroblasts and epithelial cells are receptive to the action of NGF and that NGF promotes skin and cornea ulcer healing. These observations lead to the hypothesis that NGF can be a potential useful pharmacological agent for clinical investigations. CONCLUSION: The available clinical evidences suggest that the topical application of NGF promotes healing action without side effects on corneal and cutaneous tissues damaged by chemical, physical and surgical insults and autoimmune disorders. (literal)

Prodotto di

• Regolazione della sintesi di neurotrofine nella depresione: studio sul modello animale di deprivazione sociale ed ambientale. (SV.P16.007.002) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• LUIGI ALOE (Unità di personale interno)
• PAOLA TIRASSA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Regolazione della sintesi di neurotrofine nella depresione: studio sul modello animale di deprivazione sociale ed ambientale. (SV.P16.007.002) (Modulo)

Autore CNR di

• LUIGI ALOE (Unità di personale interno)
• PAOLA TIRASSA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Pharmacological research (Rivista)

Insieme di parole chiave di

• Parole chiave di "The topical application of nerve growth factor as a pharmacological tool for human corneal and skin ulcers" (Insieme di parole chiave)