Novel role of triazenes in haematological malignancies: Pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Novel role of triazenes in haematological malignancies: Pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• (a)Caporaso; P,(b)Turriziani; M, (c) Venditti A, (d)Marchesi F, (c)Buccisano F, (e)Tirindelli MC, (f) Alvino E, (a)Garbin A (d)Tortorelli G, (d)Toppo L, (d,f) Bonmassar E, (a)D'Atri S,(c) Amadori S. (2007)
  Novel role of triazenes in haematological malignancies: Pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia.
  in DNA repair (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• (a)Caporaso; P,(b)Turriziani; M, (c) Venditti A, (d)Marchesi F, (c)Buccisano F, (e)Tirindelli MC, (f) Alvino E, (a)Garbin A (d)Tortorelli G, (d)Toppo L, (d,f) Bonmassar E, (a)D'Atri S,(c) Amadori S. (literal)

Pagina inizio

• 1179 (literal)

Pagina fine

• 1186 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact factor = 5.868 ( lista I.F. del 2006) Citations = 7 in Web of knoledge Citations = 8 in Scopus (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 6(8) (literal)

Rivista

• DNA repair (Rivista)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a) Laboratory of Molecular Oncology, \"Istituto Dermopatico dell'Immacolata-IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy b) Department of Internal Medicine, School of Medicine, University of Rome \"Tor Vergata\", Italy c) Department of Haematology, \"Tor Vergata\" University Hospital, Rome, Italy d) Department of Neuroscience, School of Medicine, University of Rome \"Tor Vergata\", Italy e) Department of Haematology, University \"Campus Bio-Medico\" of Rome, Italy f) Institute of Neurobiology and Molecular Medicine, \"Consiglio Nazionale delle Ricerche\", Rome, Italy (literal)

Titolo

• Novel role of triazenes in haematological malignancies: Pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia. (literal)

Abstract

• Previous studies indicated that dacarbazine and Temozolomide could be highly effective against refractory acute leukaemia. Their activity relies mainly on the generation of methyl adducts at the O6-position of guanine in DNA. High levels of O6-methylguanine-DNA methyltransferase (MGMT) or a defective mismatch repair (MMR) system, are associated with cellular resistance to triazenes. The MGMT inhibitor, O6-(4-bromothenyl)guanine (Lomeguatrib), can restore in vitro sensitivity to Temozolomide in MMR-proficient blasts. In the early 1970s we discovered that, in vivo, triazene compounds induce the appearance of novel transplantation antigens in murine leukaemia (“Chemical Xenogenization”, CX). Non-self peptides presented by class I MHC molecules are generated by triazene-induced somatic mutations, affecting retroviral sequences that are detectable in the mouse genome. Moreover, preliminary experiments suggested that human cancer cells can also undergo CX. Therefore, we designed a chemo-immunotherapy strategy in leukaemic patients as follows: (a) cytoreduction and a hypothetical CX phase, i.e. treatment with Lomeguatrib (to suppress MGMT activity) and Temozolomide (to kill sensitive blas (literal)

Prodotto di

• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• ENZO BONMASSAR (Unità di personale esterno)
• ESTER ALVINO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Novel role of triazenes in haematological malignancies: Pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)

Autore CNR di

• ESTER ALVINO (Unità di personale interno)
• ENZO BONMASSAR (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• DNA repair (Rivista)

Insieme di parole chiave di

• Keywords of "Novel role of triazenes in haematological malignancies: Pilot study of Temozolomide, Lomeguatrib and IL-2 in the chemo-immunotherapy of acute leukaemia." (Insieme di parole chiave)