http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4786

The timing of differentiation of adult hippocampal neurons is crucial for spatial memory (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

The timing of differentiation of adult hippocampal neurons is crucial for spatial memory (Articolo in rivista) (literal)

Anno

2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1371/journal.pbio.0060246 (literal)

Alternative label

Farioli-Vecchioli S.1#,Saraulli D. 2,3#,Costanzi M. 2,3#, Pacioni S.4#, Cinà I. 1, Aceti M. 2, Micheli L. 1, Bacci A. 4, Cestari V. 2,3, Tirone F. 1 (2008)
The timing of differentiation of adult hippocampal neurons is crucial for spatial memory
in PLoS biology; PUBLIC LIBRARY OF SCIENCE, SAN FRANCISCO (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Farioli-Vecchioli S.1#,Saraulli D. 2,3#,Costanzi M. 2,3#, Pacioni S.4#, Cinà I. 1, Aceti M. 2, Micheli L. 1, Bacci A. 4, Cestari V. 2,3, Tirone F. 1 (literal)

Pagina inizio

2188 (literal)

Pagina fine

2204 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

# These authors contributed equally to this work. Impact Factor 13.5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0060246 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

6 (literal)

Rivista

PLoS biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

17 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

10 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1 - CNR, Istituto di Neurobiologia e Medicina molecolare / Fondazione S. Lucia, Rome, Italy; 2 - CNR, Istituto di Neuroscienze, Rome, Italy; 3 - LUMSA University, Faculty of Educational Science, Rome, Italy; 4 - European Brain Research Institute, Rome, Italy (literal)

Titolo

The timing of differentiation of adult hippocampal neurons is crucial for spatial memory (literal)

Abstract

Adult neurogenesis in the dentate gyrus plays a critical role in hippocampus-dependent spatial learning. It remains unknown, however, how new neurons become functionally integrated into spatial circuits and contribute to hippocampus-mediated forms of learning and memory. To investigate these issues, we used a mouse model in which the differentiation of adult-generated dentate gyrus neurons can be anticipated by conditionally expressing the pro-differentiative gene PC3 (Tis21/BTG2) in nestin-positive progenitor cells. In contrast to previous studies that affected the number of newly generated neurons, this strategy selectively changes their timing of differentiation. New, adult-generated dentate gyrus progenitors, in which the PC3 transgene was expressed, showed accelerated differentiation and significantly reduced dendritic arborization and spine density. Functionally, this genetic manipulation specifically affected different hippocampus-dependent learning and memory tasks, including contextual fear conditioning, and selectively reduced synaptic plasticity in the dentate gyrus. Morphological and functional analyses of hippocampal neurons at different stages of differentiation, following transgene activation within defined time-windows, revealed that the new, adult-generated neurons up to 3-4 weeks of age are required not only to acquire new spatial information but also to use previously consolidated memories. Thus, the correct unwinding of these key memory functions, which can be an expression of the ability of adult-generated neurons to link subsequent events in memory circuits, is critically dependent on the correct timing of the initial stages of neuron maturation and connection to existing circuits. (literal)

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