DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• (1)MaraniC, (2) AlvinoE, (3) Caporali C, (4) Vigili MG, (4) Mancini G, (1) Rahimi S. (2007)
  DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck.
  in Histopathology (Oxf., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• (1)MaraniC, (2) AlvinoE, (3) Caporali C, (4) Vigili MG, (4) Mancini G, (1) Rahimi S. (literal)

Pagina inizio

• 780 (literal)

Pagina fine

• 788 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact factor = 3.791 Citations = 3 in Web of knoledge (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 50/6 (literal)

Rivista

• Histopathology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• (1) Department of Pathology, Ospedale San Carlo-IDI IRCCS, Rome,Italy; (2)Institute of Neurobiology and Molecular Medicine, Tor Vergata Research Area, National Research Council, Rome, Italy (3) Laboratory of Molecular Oncology, IDI IRCCS, Rome, Italy; (4)Department of Oto-Rhino-Laryngology/Head and Neck Surgery, Ospedale San Carlo-IDI IRCCS, Rome, Italy (literal)

Titolo

• DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck. (literal)

Abstract

• AIMS: To examine the expression of DNA mismatch repair (MMR) proteins and the presence of microsatellite instability (MSI) in seven primary mucosal melanomas of the head and neck (MMHN). METHODS AND RESULTS: Haematoxylin and eosin staining and immunohistochemical analysis for routine diagnostic markers and for MMR proteins were performed. Six cases were examined for MSI. Four cases were monomorphous and three cases were pleomorphic type MMHN. Melanocytic markers were positive in all cases. Immunoreactivity for MMR proteins was weak in normal epithelium. The neoplastic tissue in six cases showed positivity for all MMR proteins with different percentages. One case showed weak positivity for hMSH2 and hMSH6 and no immunoreactivity for hMLH1 or hPMS2. Staining intensity was higher in tumour cells than in matched normal mucosa in three cases for hMSH2 and hMLH1 and in two cases for hPMS2. None of the examined cases showed MSI. CONCLUSIONS: Expression of hMSH2 and hMLH1 proteins was up-regulated in three cases, whereas in two cases that of hPMS2 was increased. hMSH6 expression was comparable to that of normal cells in all cases. The percentage of positive neoplastic cells and the intensi (literal)

Prodotto di

• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• ESTER ALVINO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)

Autore CNR di

• ESTER ALVINO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Histopathology (Rivista)

Insieme di parole chiave di

• Keywords of "DNA mismatch repair protein expression and microsatellite instability in primary mucosal melanomas of the head and neck." (Insieme di parole chiave)