Mimics of Ganglioside GM1 as Cholera Toxin Ligands: Replacement of the GalNAC Residue (Articolo in rivista)

Type
Label
  • Mimics of Ganglioside GM1 as Cholera Toxin Ligands: Replacement of the GalNAC Residue (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1039/b210503a (literal)
Alternative label
  • Bernardi A.; Arosio D.; Manzoni L.; Monti D.; Posteri H.; Potenza D.; Mari S.; Jiménez-Barbero J. (2003)
    Mimics of Ganglioside GM1 as Cholera Toxin Ligands: Replacement of the GalNAC Residue
    in Organic & biomolecular chemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bernardi A.; Arosio D.; Manzoni L.; Monti D.; Posteri H.; Potenza D.; Mari S.; Jiménez-Barbero J. (literal)
Pagina inizio
  • 785 (literal)
Pagina fine
  • 792 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Bernardi A.; Arosio D.; Posteri H.; Potenza D.; Mari S.; Università degli Studi di Milano, Dipartimento di Chimica Organica e Industriale, Via Venezian 21, I-20133 Milano, Italy Manzoni L.; CNR - Istituto di Scienze e Tecnologie Molecolari, Via Golgi 19, I-20133 Milano, Italy Jiménez-Barbero J.; CSIC, Ctr Invest Biol, Dept Estructura & Func Prot, E-28006 Madrid, Spain (literal)
Titolo
  • Mimics of Ganglioside GM1 as Cholera Toxin Ligands: Replacement of the GalNAC Residue (literal)
Abstract
  • Two new cholera toxin (CT) ligands (4 and 5) are described. The new ligands were designed starting from the known GM1 mimics 2 and 3 by replacement of their GalNAc residue with the C4 isomer GlcNAc. As predicted by molecular modelling, the conformational properties of the equivalent pairs 2-4 and 3-5 are very similar and their affinity for CT is of the same order of magnitude. NMR experiments have also proved that 5 occupies the GM1-binding site of the toxin and have revealed its bound conformation. (literal)
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