Apoptotic Death Induces Abeta Production and Fibril Formation to a Much Larger Extent than Necrotic-Like Death in CGNs. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Apoptotic Death Induces Abeta Production and Fibril Formation to a Much Larger Extent than Necrotic-Like Death in CGNs. (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Alternative label

• Simona Cicconi; Antonietta Gentile; Maria Teresa Ciotti; Tiziana Parasassi; Annalucia Serafino; Pietro Calissano (2007)
  Apoptotic Death Induces Abeta Production and Fibril Formation to a Much Larger Extent than Necrotic-Like Death in CGNs.
  in Journal of Alzheimer's disease
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Simona Cicconi; Antonietta Gentile; Maria Teresa Ciotti; Tiziana Parasassi; Annalucia Serafino; Pietro Calissano (literal)

Pagina inizio

• 211 (literal)

Pagina fine

• 220 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 12 (literal)

Rivista

• Journal of Alzheimer's disease (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Neurobiology and Molecular Medicine, CNR, Roma, and European Brain Research Institute (EBRI), Roma, Italy (literal)

Titolo

• Apoptotic Death Induces Abeta Production and Fibril Formation to a Much Larger Extent than Necrotic-Like Death in CGNs. (literal)

Abstract

• In this study we report that apoptotic death of primary cultures of cerebellar granule neurons is accompanied by release of thioflavin-binding proteins – indicative of the presence of â-sheet structures – and fibril formation in the culture medium. When the same neurons are subjected to an excytotoxic death caused by 100 ìM glutamate exposure, the amount of thioflavin binding is markedly reduced. Western blot analysis shows that fibrils contain monomers, dimers and trimers of amyloid-â (Aâ) which, when observed at the electron microscope, have morphologies reminiscent of fibrils of senile plaques. These findings demonstrate that triggering an apoptotic pathway leads to â-sheet transition and fibril formation of a protein primarily involved in Alzheimer's disease and may be of direct relevance to the possible link between apoptosis and this neuropathology. (literal)

Prodotto di

• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)
• Meccanismi ossidoriduttivi nelle patologie degenerative ed infiammatorie (ME.P04.005.003) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• ANNALUCIA SERAFINO (Persona)
• PIETRO CALISSANO (Persona)
• MARIA TERESA CIOTTI (Persona)
• Antonietta Gentile (Unità di personale esterno)
• TIZIANA PARASASSI (Persona)

Insieme di parole chiave

• Keywords of "Apoptotic Death Induces Abeta Production and Fibril Formation to a Much Larger Extent than Necrotic-Like Death in CGNs." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• TIZIANA PARASASSI (Persona)
• ANNALUCIA SERAFINO (Persona)
• MARIA TERESA CIOTTI (Persona)
• Antonietta Gentile (Unità di personale esterno)
• PIETRO CALISSANO (Persona)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)
• Meccanismi ossidoriduttivi nelle patologie degenerative ed infiammatorie (ME.P04.005.003) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of Alzheimer's disease (Rivista)

Insieme di parole chiave di

• Keywords of "Apoptotic Death Induces Abeta Production and Fibril Formation to a Much Larger Extent than Necrotic-Like Death in CGNs." (Insieme di parole chiave)