Gemcitabine treatment of experimental C6 glioma: the effects on cell cycle and apoptotic rate. (Articolo in rivista)

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  • Gemcitabine treatment of experimental C6 glioma: the effects on cell cycle and apoptotic rate. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • GIULIA CARPINELLI1, BARBARA BUCCI2, IGEA D'AGNANO3, ROSSELLA CANESE1, FABRIZIO CAROLI4, LAURA RAUS4, ERCOLE BRUNETTI2, DIANA GIANNARELLI4, FRANCA PODO1 and CARMINE M. CARAPELLA4 (2006)
    Gemcitabine treatment of experimental C6 glioma: the effects on cell cycle and apoptotic rate.
    in Anticancer research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • GIULIA CARPINELLI1, BARBARA BUCCI2, IGEA D'AGNANO3, ROSSELLA CANESE1, FABRIZIO CAROLI4, LAURA RAUS4, ERCOLE BRUNETTI2, DIANA GIANNARELLI4, FRANCA PODO1 and CARMINE M. CARAPELLA4 (literal)
Pagina inizio
  • 3017 (literal)
Pagina fine
  • 3024 (literal)
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  • 26/4B (literal)
Rivista
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  • 8 (literal)
Note
  • PubMe (literal)
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  • 1Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome; 2Research Center, Ospedale San Pietro AFaR-FBF, Via Cassia 600, Rome; 3Department of Pharmacology, University of Milan, and Istituto Tecnologie Biomediche, CNR, Via Fratelli Cervi, 93, Segrate (MI); 4Department of Neuroscience and Statistical Unit, Regina Elena Nat. Cancer Institute, Via E. Chianesi 53, Rome, Italy (literal)
Titolo
  • Gemcitabine treatment of experimental C6 glioma: the effects on cell cycle and apoptotic rate. (literal)
Abstract
  • Gemcitabine (dFdCyd) is a deoxycytidine analogue showing a broad spectrum of cytotoxic activity; additionally, at non-cytotoxic concentrations, it is a potent radiosensitiser. Its in vitro and in vivo effects were studied on C6 rat glioma. In vitro, dFdCyd induced an increase in S-phase cells at the end of treatment, with a reduction in G1 and G2 cell cycle-phase cells and relevant effects on the apoptotic rate. The in vivo effects of dFdCyd were studied on rats bearing intracranial C6 glioma. The drug was administered at a dose of 120 mg/Kg every 3 days x 4 doses. A significant effect on tumour growth was detected by longitudinal MRI analyses. Furthermore, the drug induced an inhibitory effect on tumour growth, 72 h after a 300 mg/Kg single dose. Analyses performed on tumour specimens showed relevant G1-phase accumulation and about 45% apoptotic cells. The present results justify further studies to determine the potential efficacy of dFdCyd in the treatment of malignant gliomas. (literal)
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