Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1189/jlb.1105690 (literal)

Alternative label

• Sanarico N.a, Ciaramella A., Sacchi A., Bernasconi D., Bossu P., Mariani F.b, Colizzi V.c, Vendetti S. (2006)
  Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response
  in Journal of leukocyte biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sanarico N.a, Ciaramella A., Sacchi A., Bernasconi D., Bossu P., Mariani F.b, Colizzi V.c, Vendetti S. (literal)

Pagina inizio

• 555 (literal)

Pagina fine

• 562 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor = 4.572 E-pub 2006 June 29 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 80 (literal)

Rivista

• Journal of leukocyte biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• b = Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy; a,c = Department of Biology, University of Rome Tor Vergata, Rome, Italy. (literal)

Titolo

• Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response (literal)

Abstract

• Interleukin (IL)-2 plays an important role in the control of the immune responses, and it is released in a variety of tissues in response to inflammatory stimuli. As monocytes and mature dendritic cells (DCs) express CD25, the high-affinity subunit of IL-2 receptor, we examined the effect of exogenous IL-2 on the in vitro generation and maturation of DCs from monocytes. Human monocyte-derived DCs (MDDCs) were generated by culturing monocytes with granulocyte macrophage-colony stimulating factor (GM-CSF) and IL-4 in the presence or absence of IL-2. The cytokine was added at the beginning and after 5 days of culture. Our findings indicate that IL-2 does induce monocytes to differentiate into DCs with the same morphology and phenotype of that obtained in the presence of GM-CSF and IL-4 alone, but with some distinctive functional properties. DCs differentiated in the presence of IL-2 secreted significantly more IL-1beta, TNF-alpha, and IL-12 p70 in response to lipopolysaccharide stimulation and induced allogeneic, naive T cells to release a significantly higher amount of interferon-gamma if compared with DCs obtained by culturing monocytes with GM-CSF and IL-4. These results indicate unrecognized effects of IL-2 on human MDDCs and suggest that an IL-2-rich environment during differentiation and maturation of DCs can modify their T helper cell-inducing properties. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Interazione ospite-patogeno per un nuovo vaccino anti-TB_ (ME.P04.005.002) (Modulo)

Autore CNR

• Nunzia Sanarico (Persona)
• FRANCESCA MARIANI (Persona)

Incoming links:

Autore CNR di

• FRANCESCA MARIANI (Persona)
• Nunzia Sanarico (Persona)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Interazione ospite-patogeno per un nuovo vaccino anti-TB_ (ME.P04.005.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of leukocyte biology (Rivista)