Transcriptional profile of the immune response in the lungs of patients with active tuberculosis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Transcriptional profile of the immune response in the lungs of patients with active tuberculosis (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.clim.2006.06.008 (literal)

Alternative label

• Grassi M.a, Bocchino M.L.b, Marruchella A.b, Volpe E.a,c, Saltini C.b, Colizzi V.c, Mariani F.a. (2006)
  Transcriptional profile of the immune response in the lungs of patients with active tuberculosis
  in Clinical immunology (Orlando, Fla., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Grassi M.a, Bocchino M.L.b, Marruchella A.b, Volpe E.a,c, Saltini C.b, Colizzi V.c, Mariani F.a. (literal)

Pagina inizio

• 100 (literal)

Pagina fine

• 107 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor = 3.606 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 121 (literal)

Rivista

• Clinical immunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a = Institute of Neurobiology and Molecular Medicine (INMM), National Research Council, Via del Fosso del Cavaliere, 100, 00133 Rome, Italy; b = Division of Respiratory Medicine of the University of Rome “Tor Vergata” at the National Institute for Infectious Diseases “L. Spallanzani”-IRCCS, Rome, Italy; c = Biology Department, University of Rome “Tor Vergata”, Rome, Italy. (literal)

Titolo

• Transcriptional profile of the immune response in the lungs of patients with active tuberculosis (literal)

Abstract

• Despite advances in diagnosis and treatment, Mycobacterium tuberculosis causes active disease in about 8 million people worldwide annually. The study of the interplay between the host and the pathogen at the site of infection in human TB may contribute to elucidate the pathogenesis of the disease. In this work, using macroarray technology and real-time PCR, we analyzed the modulation of 847 genes encoding immune-inflammatory mediators in BALF samples of patients affected by active pulmonary TB (PTB) and control patients affected by non-TB diseases. The data show that the PTB milieu contains a complex network of gene activation. Different genes with adhesive properties and involved in tissue repair and fibrosis were modulated. In TB patients, we observed the up-regulation of cytokines, including IFN-ã and IFN-ã pathway genes, of several apoptotic genes, and of potent transcriptional activators. These findings can contribute to elucidate the mechanisms of MTB pathogenicity in humans. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Interazione ospite-patogeno per un nuovo vaccino anti-TB_ (ME.P04.005.002) (Modulo)

Autore CNR

• FRANCESCA MARIANI (Persona)

Insieme di parole chiave

• Parole chiave di "Transcriptional profile of the immune response in the lungs of patients with active tuberculosis" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FRANCESCA MARIANI (Persona)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Interazione ospite-patogeno per un nuovo vaccino anti-TB_ (ME.P04.005.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Clinical immunology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Transcriptional profile of the immune response in the lungs of patients with active tuberculosis" (Insieme di parole chiave)