Btg2 Enhances Retinoic Acid-Induced Differentiation by Modulating Histone H4 Methylation and Acetylation. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Btg2 Enhances Retinoic Acid-Induced Differentiation by Modulating Histone H4 Methylation and Acetylation. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1128/MCB.01360-05 (literal)

Alternative label

• Daniela Passeri,1; Antonella Marcucci,1; Giovanni Rizzo,1; Monia Billi,1; Maddalena Panigada,1; Luca Leonardi,2; Felice Tirone,2; and Francesco Grignani1 (2006)
  Btg2 Enhances Retinoic Acid-Induced Differentiation by Modulating Histone H4 Methylation and Acetylation.
  in Molecular and cellular biology (Print); ASM, American society for microbiology, Washington, DC (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Daniela Passeri,1; Antonella Marcucci,1; Giovanni Rizzo,1; Monia Billi,1; Maddalena Panigada,1; Luca Leonardi,2; Felice Tirone,2; and Francesco Grignani1 (literal)

Pagina inizio

• 5023 (literal)

Pagina fine

• 5032 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor = 6.773 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://mcb.asm.org/content/26/13/5023 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 26 (literal)

Rivista

• Molecular and cellular biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 13 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Univ Perugia, Dipartimento Med Clin & Sperimentale, Policlin Monteluce, I-06100 Perugia, Italy 2. CNR, Ist Neurobiol & Med Mol, Fdn St Lucia, I-00143 Rome, Italy (literal)

Titolo

• Btg2 Enhances Retinoic Acid-Induced Differentiation by Modulating Histone H4 Methylation and Acetylation. (literal)

Abstract

• Retinoic acid controls hematopoietic differentiation through the transcription factor activity of its receptors. They act on specific target genes by recruiting protein complexes that deacetylate or acetylate histones and modify chromatin status. The regulation of this process is affected by histone methyltransferases, which can inhibit or activate transcription depending on their amino acid target. We show here that retinoic acid treatment of hematopoietic cells induces the expression of BTG2. Overexpression of this protein increases RARalpha transcriptional activity and the differentiation response to retinoic acid of myeloid leukemia cells and CD34+ hematopoietic progenitors. In the absence of retinoic acid, BTG2 is present in the RARalpha transcriptional complex, together with the arginine methyltransferase PRMT1 and Sin3A. Overexpressed BTG2 increases PRMT1 participation in the RARalpha protein complex on the RARbeta promoter, a target gene model, and enhances gene-specific histone H4 arginine methylation. Upon RA treatment Sin3A, BTG2, and PRMT1 detach from RARalpha and thereafter BGT2 and PRMT1 are driven to the cytoplasm. These events prime histone H4 demethylation and acetylation. Overall, our data show that BTG2 contributes to retinoic acid activity by favoring differentiation through a gene-specific modification of histone H4 arginine methylation and acetylation levels. (literal)

Editore

• ASM, American society for microbiology (Editore)

Prodotto di

• Sviluppo, Differenziamento e Trasformazione Cellulare (SV.P15.006.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• LUCA LEONARDI (Unità di personale interno)
• FELICE TIRONE (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Btg2 Enhances Retinoic Acid-Induced Differentiation by Modulating Histone H4 Methylation and Acetylation." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• FELICE TIRONE (Unità di personale interno)
• LUCA LEONARDI (Unità di personale interno)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Sviluppo, Differenziamento e Trasformazione Cellulare (SV.P15.006.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Molecular and cellular biology (Rivista)

Editore di

• ASM, American society for microbiology (Editore)

Insieme di parole chiave di

• Parole chiave di "Btg2 Enhances Retinoic Acid-Induced Differentiation by Modulating Histone H4 Methylation and Acetylation." (Insieme di parole chiave)