Role of Bcl-2 expression for productive herpes simplex virus 2 replication. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Role of Bcl-2 expression for productive herpes simplex virus 2 replication. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.virol.2006.08.001 (literal)

Alternative label

• Sciortino M.T.1; Perri D.2; Medici M.A.3; Grelli S.4; Serafino A.5; Borner C.6; Mastino A.7. (2006)
  Role of Bcl-2 expression for productive herpes simplex virus 2 replication.
  in Virology (N.Y.N.Y., Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sciortino M.T.1; Perri D.2; Medici M.A.3; Grelli S.4; Serafino A.5; Borner C.6; Mastino A.7. (literal)

Pagina inizio

• 136 (literal)

Pagina fine

• 146 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Epub ahead of print. Impact Factor = 3.525 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 356 (literal)

Rivista

• Virology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1-2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1,2,3,7 = Department of Microbiological, Genetic and Molecular Sciences, University of Messina, Salita Sperone 31, 98166 Messina, Italy; 4 = Department of Experimental Medicine and Biochemical Sciences, University of Rome “Tor Vergata”, Via Montpellier 1, 00141 Rome, Italy; 5 = Institute of Neurobiology and Molecular Medicine, C.N.R., Via Fosso del Cavaliere 100, 00133 Rome, Italy; 6 = Institute for Molecular Medicine and Cell Research, Albert-Ludwigs-University of Freiburg, Stefan-Meier-Strasse 17, D-79104 Freiburg, Germany. (literal)

Titolo

• Role of Bcl-2 expression for productive herpes simplex virus 2 replication. (literal)

Abstract

• Herpes simplex viruses infect a variety of cells in vitro. However, not all infected cells sustain a fully productive replication of these viruses. We have shown that, in U937 monocytoid cells, herpes simplex virus 2 (HSV-2) causes a low-productive infection characterized by apoptosis as cytopathic effect at a late stage of infection. This effect was associated with a down-regulation of the Bcl-2 protein. We therefore asked whether destabilization of Bcl-2 expression could act as a limiting factor for the productive HSV-2 infection. We found that overexpression of Bcl-2 in U937 cells dramatically increased the capability of these cells to sustain a fully productive infection, while protecting against apoptosis induced by HSV-2. Overall, our data indicate that Bcl-2 expression acts as a regulator of HSV-2 replication. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)

Autore CNR

• ANNALUCIA SERAFINO (Persona)

Insieme di parole chiave

• Keywords of "Role of Bcl-2 expression for productive herpes simplex virus 2 replication." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANNALUCIA SERAFINO (Persona)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Target Molecolari, Modelli preclinici e Immunoterapia (ME.P03.006.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Virology (Rivista)

Insieme di parole chiave di

• Keywords of "Role of Bcl-2 expression for productive herpes simplex virus 2 replication." (Insieme di parole chiave)