Alterations of rCBF and mitochondrial dysfunction in major depressive disorder: a case report. (Articolo in rivista)

Type
Label
  • Alterations of rCBF and mitochondrial dysfunction in major depressive disorder: a case report. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Gardner A, Pagani M, Wibom R, Nennesmo I, Jacobsson H, Hällström T. (2003)
    Alterations of rCBF and mitochondrial dysfunction in major depressive disorder: a case report.
    in Acta psychiatrica Scandinavica; Blackwell Munksgaard, Copenaghen (Danimarca)
    (literal)
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  • Gardner A, Pagani M, Wibom R, Nennesmo I, Jacobsson H, Hällström T. (literal)
Pagina inizio
  • 233 (literal)
Pagina fine
  • 239 (literal)
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  • 107 (literal)
Rivista
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  • 7 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • NEUROTEC Department, Division of Psychiatry, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden, Section of Nuclear Medicine, Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy, Centre for Inherited Metabolic Diseases, Huddinge University Hospital, Stockholm, Sweden, Division of Pathology, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden and Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden (literal)
Titolo
  • Alterations of rCBF and mitochondrial dysfunction in major depressive disorder: a case report. (literal)
Abstract
  • Background. A mitochondrial disease might be considered when depressive disorder is associated with diabetes mellitus or other symptoms commonly found in mitochondrial disease. Scattered rCBF decreases and increases have been reported in depressive and mitochondrial disorders. Method. A 61-year old male patient with early adult onset of depressive disorder and a slowly developing multiorgan syndrome including diabetes mellitus was investigated with 99mTc-HMPAO rCBF SPECT, and muscle biopsy to assess mitochondrial functions. Results. Alterations of rCBF were found in the patient, with the most pronounced decreases in the left dorsolateral frontal and inferior parietal lobes, and the most pronounced increases in the bilateral superior parietal lobe. Muscle biopsy revealed myopathy and decrease of mitochondrial ATP production rates (MAPRs). Conclusion. The MAPRs decreases support the suspicion of mitochondrial dysfunction in the patient. A subgroup of depressed patients may have mitochondrial dysfunctions. (literal)
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