Increased spinal cord NGF levels in rats with cobalamin (vitamin B12) deficiency. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Increased spinal cord NGF levels in rats with cobalamin (vitamin B12) deficiency. (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Alternative label

• Scalabrino G.1, Mutti E.2, Veber D.3, Aloe L.4, Corsi M.M.5, Galbiati S.6, Tredici G.7 (2006)
  Increased spinal cord NGF levels in rats with cobalamin (vitamin B12) deficiency.
  in Neuroscience letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Scalabrino G.1, Mutti E.2, Veber D.3, Aloe L.4, Corsi M.M.5, Galbiati S.6, Tredici G.7 (literal)

Pagina inizio

• 153 (literal)

Pagina fine

• 158 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor = 2.092 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 396/2 (literal)

Rivista

• Neuroscience letters (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1,2,3,5 = Institute of General Pathology, University of Milan, Via Mangiagalli 31, 20133 Milano, Italy, 1,2,3 = Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milano, Italy; 4 = Institute of Neurobiology and Molecular Medicine, National Research Council (CNR), Viale Marx 15, 00137 Roma, Italy; 6,7 = Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20052 Monza, Italy. (literal)

Titolo

• Increased spinal cord NGF levels in rats with cobalamin (vitamin B12) deficiency. (literal)

Abstract

• We have recently demonstrated that the neuropathological morphological alterations caused by cobalamin (Cbl) deficiency in the rat central nervous system are related to the vitamin's inability to modulate the synthesis of some neurotoxic and neurotrophic agents in opposite directions. In the present study, we measured nerve growth factor (NGF) levels in the spinal cord (SC) and cerebrospinal fluid (CSF) of rats made Cbl-deficient (Cbl-D) by means of total gastrectomy (TG) or a Cbl-D diet. In both cases, Cbl deficiency increased SC and CSF NGF levels after the appearance of myelinolytic lesions in the SC white matter (SCWM) (i.e. after the second post-TG month), and these changes were normalised by Cbl treatment in the 4-month-totally-gastrectomised (TGX) rats. Intracerebroventricular (i.c.v.) anti-NGF-antibody treatment prevented the onset of the myelinolytic SCWM lesions in the 2-month-TGX rats (i.e. when SC and CSF NGF levels are still normal) and normalised the ultrastructure of the SCWM in the 4-month-TGX rats, which was however worsened by the i.c.v. administration of NGF. These findings demonstrate that: (i) Cbl deficiency increases SC and CSF NGF levels; and (ii) endogenous NGF seems to play a noxious role in the progression of rat Cbl-D central neuropathy. (literal)

Prodotto di

• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• LUIGI ALOE (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Increased spinal cord NGF levels in rats with cobalamin (vitamin B12) deficiency." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR di

• LUIGI ALOE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience letters (Rivista)

Insieme di parole chiave di

• Keywords of "Increased spinal cord NGF levels in rats with cobalamin (vitamin B12) deficiency." (Insieme di parole chiave)