http://www.cnr.it/ontology/cnr/individuo/prodotto/ID46599
Over-expression of functional Saccharomyces cerevisiae GUP1, induces proliferation of intracellular membranes containing ER and Golgi resident proteins. (Articolo in rivista)
- Type
- Label
- Over-expression of functional Saccharomyces cerevisiae GUP1, induces proliferation of intracellular membranes containing ER and Golgi resident proteins. (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bbamem.2010.12.005 (literal)
- Alternative label
Bleve G., Di Sansebastiano G., Grieco F. (2011)
Over-expression of functional Saccharomyces cerevisiae GUP1, induces proliferation of intracellular membranes containing ER and Golgi resident proteins.
in Biochimica et biophysica acta. Biomembranes
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bleve G., Di Sansebastiano G., Grieco F. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- Impact Factor (2013): 3.431 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.sciencedirect.com/science?_ob=MiamiImageURL&_cid=271033&_user=6689788&_pii=S0005273610004402&_check=y&_origin=browseVolIssue&_zone=rslt_list_item&_coverDate=2011-03-31&_docsubtype=fla&wchp=dGLzVlS-zSkzS&md5=6155b05dabda76120aef811e74a47bdc&pid=1-s2.0-S0005273610004402-main.pdf (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Università del Salento
CNR-ISPA (literal)
- Titolo
- Over-expression of functional Saccharomyces cerevisiae GUP1, induces proliferation of intracellular membranes containing ER and Golgi resident proteins. (literal)
- Abstract
- High-level expression of the GUP1 gene in Saccharomyces cerevisiae resulted in the formation of proliferated
structures, which hosted endoplasmic reticulum (ER), Golgi and itinerant proteins. The GUP1 over-expression
enhanced ER biogenesis, as shown by the coordinated increased transcription rate of genes involved in both ER
and Golgi metabolism and in phospholipids biosynthesis. The formation of Gup1-induced proliferation revealed
that it depended on an intact unfolded protein response, because their assembly was reported to be lethal to
yeast strains unable to initiate the UPR (Unfolded Protein Response) pathway. GUP1 over-expression affected
global ER and Golgi structure and resulted in the biogenesis of novel membrane arrays with Golgi and ER hybrid
composition. In fact, a number of ER and Golgi resident proteins together with itinerant proteins that normally
cycle between ER and Golgi, were localized in the proliferated stacked membranes. The described assembling of
novel membrane structures was affected by the functionality of the Gup1 O-acyltransferase domain, which
regulates the Gup1 protein role as remodelase in the glycosylphosphatidylinositol (GPI) anchored proteins
biosynthesis. To our knowledge, we presented the first evidence of sub cellular modifications in response overexpressionof a GPI-anchor remodelase in S. cerevisiae. (literal)
- Prodotto di
- Autore CNR
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi