Nerve growth factor effect on human primary fibroblastic-keratocytes: Possible mechanism during corneal healing. (Articolo in rivista)

Type
Label
  • Nerve growth factor effect on human primary fibroblastic-keratocytes: Possible mechanism during corneal healing. (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Micera A.1, Lambiase A.2, Puxeddu I.3, Aloe L.4, Stampachiacchiere B.5, Levi-Schaffer F.6, Bonini S.7, Bonini S.8 (2006)
    Nerve growth factor effect on human primary fibroblastic-keratocytes: Possible mechanism during corneal healing.
    in Experimental Eye Research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Micera A.1, Lambiase A.2, Puxeddu I.3, Aloe L.4, Stampachiacchiere B.5, Levi-Schaffer F.6, Bonini S.7, Bonini S.8 (literal)
Pagina inizio
  • 747 (literal)
Pagina fine
  • 757 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Impact Factor = 2.776 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 83 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1,2,5,8 = CIR Laboratory of Ophthalmology, University Campus Bio-Medico and G.B.Bietti, Foundation, Via Emilio Longoni 83, 00155 Rome, Italy; 1,3,6 = Department of Pharmacology, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel; 4,7 = Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy; 7 = IRCCS San Raffaele, Rome, Italy. (literal)
Titolo
  • Nerve growth factor effect on human primary fibroblastic-keratocytes: Possible mechanism during corneal healing. (literal)
Abstract
  • In response to corneal injury, cytokines and growth factors play a crucial role by influencing epithelial-stromal interaction during the healing and reparative processes which may resolve in tissue remodeling and fibrosis. While transforming growth factor-beta1 (TGF-beta1) is considered the main profibrogenic modulator of these process, recently the nerve growth factor (NGF) appears as a pleiotropic modulator of wound-healing and inflammatory responses. Interestingly in the cornea, where NGF, trkA(NGFR) and p75(NTR) are expressed by epithelial cells and keratocytes, the NGF eye-drop induces the healing of neurotrophic or autoimmune corneal ulcers. During corneal healing, quiescent keratocytes are replaced by active fibroblast-like keratocytes/myofibroblasts. While the NGF effect on epithelial cells has been investigated, no data are reported for NGF effects on fibroblastic-keratocytes, during corneal healing. NGF, trkA(NGFR) and p75(NTR) were found expressed by fibroblastic-keratocytes. NGF was able to induce fibroblastic-keratocyte differentiation into myofibroblasts, migration, Metalloproteinase-9 expression/activity and contraction of a 3D collagen gel, without affecting their proliferation and collagen production. These data also show a two-directional control of fibroblastic-keratocytes by NGF and TGF-beta1. To sum up, the findings of this study indicate that NGF can modulate some functional activities of fibroblastic-keratocytes, thus substantiating the healing effects of NGF on corneal wound-healing. (literal)
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