http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4657
Nerve growth factor effect on human primary fibroblastic-keratocytes: Possible mechanism during corneal healing. (Articolo in rivista)
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- Label
- Nerve growth factor effect on human primary fibroblastic-keratocytes: Possible mechanism during corneal healing. (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Alternative label
Micera A.1, Lambiase A.2, Puxeddu I.3, Aloe L.4, Stampachiacchiere B.5, Levi-Schaffer F.6, Bonini S.7, Bonini S.8 (2006)
Nerve growth factor effect on human primary fibroblastic-keratocytes: Possible mechanism during corneal healing.
in Experimental Eye Research
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- Micera A.1, Lambiase A.2, Puxeddu I.3, Aloe L.4, Stampachiacchiere B.5, Levi-Schaffer F.6, Bonini S.7, Bonini S.8 (literal)
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- ISI Web of Science (WOS) (literal)
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- 1,2,5,8 = CIR Laboratory of Ophthalmology, University Campus Bio-Medico and G.B.Bietti, Foundation, Via Emilio Longoni 83, 00155 Rome, Italy;
1,3,6 = Department of Pharmacology, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel;
4,7 = Institute of Neurobiology and Molecular Medicine, National Research Council, Rome, Italy;
7 = IRCCS San Raffaele, Rome, Italy.
(literal)
- Titolo
- Nerve growth factor effect on human primary fibroblastic-keratocytes: Possible mechanism during corneal healing. (literal)
- Abstract
- In response to corneal injury, cytokines and growth factors play a crucial role by influencing epithelial-stromal interaction during the healing and reparative processes which may resolve in tissue remodeling and fibrosis. While transforming growth factor-beta1 (TGF-beta1) is considered the main profibrogenic modulator of these process, recently the nerve growth factor (NGF) appears as a pleiotropic modulator of wound-healing and inflammatory responses. Interestingly in the cornea, where NGF, trkA(NGFR) and p75(NTR) are expressed by epithelial cells and keratocytes, the NGF eye-drop induces the healing of neurotrophic or autoimmune corneal ulcers. During corneal healing, quiescent keratocytes are replaced by active fibroblast-like keratocytes/myofibroblasts. While the NGF effect on epithelial cells has been investigated, no data are reported for NGF effects on fibroblastic-keratocytes, during corneal healing. NGF, trkA(NGFR) and p75(NTR) were found expressed by fibroblastic-keratocytes. NGF was able to induce fibroblastic-keratocyte differentiation into myofibroblasts, migration, Metalloproteinase-9 expression/activity and contraction of a 3D collagen gel, without affecting their proliferation and collagen production. These data also show a two-directional control of fibroblastic-keratocytes by NGF and TGF-beta1. To sum up, the findings of this study indicate that NGF can modulate some functional activities of fibroblastic-keratocytes, thus substantiating the healing effects of NGF on corneal wound-healing.
(literal)
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