IFN-beta reverses the lipopolysaccharide-induced proteome modifications in treated astrocytes. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• IFN-beta reverses the lipopolysaccharide-induced proteome modifications in treated astrocytes. (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jneuroim.2010.01.002 (literal)

Alternative label

• Vergara D, Martignano R, Bonsegna S, De Nuccio F, Santino A, Nicolardi G, Maffia M (2010)
  IFN-beta reverses the lipopolysaccharide-induced proteome modifications in treated astrocytes.
  in Journal of neuroimmunology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Vergara D, Martignano R, Bonsegna S, De Nuccio F, Santino A, Nicolardi G, Maffia M (literal)

Pagina inizio

• 115 (literal)

Pagina fine

• 120 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• IF: 2.786 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 221 (literal)

Rivista

• Journal of neuroimmunology (Rivista)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni 73100, Lecce, Italy Laboratory of Anatomy, Department of Biological and Environmental Sciences and Technologies, University of Salento, via Monteroni 73100, Lecce, Italy Institute of Sciences of Food Production CNR-ISPA, Unit of Lecce, Italy Laboratory of Clinical Proteomic, \"Vito Fazzi\" Hospital, ASL-Lecce, Italy (literal)

Titolo

• IFN-beta reverses the lipopolysaccharide-induced proteome modifications in treated astrocytes. (literal)

Abstract

• Astrocytes have a key role in the pathogenesis of several diseases, including multiple sclerosis, and are proposed as a possible target for immunotherapy. Our earlier study reported that astrocytes treated with IFN-² modified their biomechanical properties possibly due to changes in the expression of the proteins involved in cytoskeleton organization and other important physiological processes. To gain insight into the mechanism underlying IFN-² action during inflammation, we stimulated astrocytes with LPS, a bacterial wall component used as a model for both in vitro and in vivo immunological stimulation of microglia and astrocytes. We showed that IFN-² reverses the effects of LPS on the proteome of astrocytes. To better examine this result, we performed a proteomic analysis of astrocytes treated with LPS or LPS plus IFN-². Treatment with LPS caused increases both in a series of proteins mainly involved in cytoskeletal changes and in protein degradation, as well as protective enzymes like superoxide dismutase. IFN-² reverses LPS effects on astrocytes proteome, supporting its protective role during inflammatory insults (literal)

Prodotto di

• Biotecnologie per la qualità e sicurezza degli alimenti (AG.P05.007.001) (Modulo)
• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)

Autore CNR

• ANGELO SANTINO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "IFN-beta reverses the lipopolysaccharide-induced proteome modifications in treated astrocytes." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANGELO SANTINO (Unità di personale interno)

Prodotto

• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)
• Biotecnologie per la qualità e sicurezza degli alimenti (AG.P05.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neuroimmunology (Rivista)

Insieme di parole chiave di

• Keywords of "IFN-beta reverses the lipopolysaccharide-induced proteome modifications in treated astrocytes." (Insieme di parole chiave)