http://www.cnr.it/ontology/cnr/individuo/prodotto/ID46515
Investigations of Fungal Secondary Metabolites with Anticancer Activity (Articolo in rivista)
- Type
- Label
- Investigations of Fungal Secondary Metabolites with Anticancer Activity (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1021/np900731p (literal)
- Alternative label
Saidou Balde E., Andolfi A., Bruyère C., Cimmino A., Lamoral-Theys D., Vurro M., Van Damme M., Altomare C., Mathieu V., Kiss R., Evidente A. (2010)
Investigations of Fungal Secondary Metabolites with Anticancer Activity
in Journal of natural products (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Saidou Balde E., Andolfi A., Bruyère C., Cimmino A., Lamoral-Theys D., Vurro M., Van Damme M., Altomare C., Mathieu V., Kiss R., Evidente A. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Laboratoire de Toxicologie and Laboratoire de Chimie Analytique, Toxicologie et Chimie Physique Applique´e, Institut de Pharmacie,
UniVersite´ Libre de Bruxelles (ULB), Brussels, Belgium, Dipartimento di Scienze del Suolo, della Pianta, dell'Ambiente e delle Produzioni
Animali, UniVersita` di Napoli Federico II, Portici, Italy, and Institute of Sciences of Food Productions, CNR, Bari, Italy (literal)
- Titolo
- Investigations of Fungal Secondary Metabolites with Anticancer Activity (literal)
- Abstract
- Fourteen metabolites, isolated from phytopathogenic and toxigenic fungi, were evaluated for their in vitro antigrowth
activity for six distinct cancer cell lines, using the MTT colorimetric assay. Bislongiquinolide (1) and dihydrotrichodimerol
(5), which belong to the bisorbicillinoid structural class, displayed significant growth inhibitory activity against the six
cancer cell lines studied, while the remaining compounds displayed weak or no activity. The data show that 1 and 5
have similar growth inhibitory activities with respect to those cancer cell lines that display certain levels of resistance
to pro-apoptotic stimuli or those that are sensitive to apoptosis. Quantitative videomicroscopy analysis revealed that 1
and 5 exert their antiproliferative effect through cytostatic and not cytotoxic activity. The preliminary results from the
current study have stimulated further structure-activity investigations with respect to the growth inhibitory activity of
compounds belonging to the bisorbicillinoid group. (literal)
- Prodotto di
- Autore CNR
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