In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/jcp.20182 (literal)

Alternative label

• Noonan Douglas M. 1; Severino Anna 2; Morini Monica 1; Tritarelli Alessandra 2; Manente Lucrezia 2; D'Agnano Igea 3; Starace Giuseppe 3; Baldi Alfonso 2; Lombardi Daniela 4; Albini Adriana 5; Felsani Armando 3; Paggi Marco G. 2 (2005)
  In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells.
  in Journal of cellular physiology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Noonan Douglas M. 1; Severino Anna 2; Morini Monica 1; Tritarelli Alessandra 2; Manente Lucrezia 2; D'Agnano Igea 3; Starace Giuseppe 3; Baldi Alfonso 2; Lombardi Daniela 4; Albini Adriana 5; Felsani Armando 3; Paggi Marco G. 2 (literal)

Pagina inizio

• 922 (literal)

Pagina fine

• 928 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/15389561 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 202 (literal)

Rivista

• Journal of cellular physiology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Tumor Progression Section, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, Genova, Italy; 2. Laboratory C, Department for the Development of Therapeutic Programs, Center for Experimental Research, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, Rome, Italy; 3. CNR, Istituto di Neurobiologia e Medicina Molecolare, Viale Marx 43, Rome, Italy; 4. Department of Experimental Medicine, University of L'Aquila, Via Vetoio, Coppito 2, L'Aquila, Italy; 5. Molecular Oncology Laboratory, Istituto Nazionale per la Ricerca sul Cancro, Largo Rosanna Benzi, Genova, Italy. (literal)

Titolo

• In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells. (literal)

Abstract

• The cell cycle regulatory pathway responsible for the control of the late-G1 checkpoint is found recurrently altered in human malignant melanoma, often due to lack of functional p16 or pRb (pRb-1) proteins. Here we examined the ability of p16-derived peptides to mimic p16 function in two exemplary human melanoma cell lines: the p16-defective, pRb-positive A375M cells and p16-positive, pRb-defective A2058 cells. The synthetic p16-mimicking peptides strongly induced apoptosis in p16-, pRb+ A375M cells in vitro, while they had significantly less activity on p16+, pRb- A2058 cells. The most active p16-mimicking peptide, p16-AP9, also potently inhibited in vivo growth of the A375M melanoma. Treated tumors showed a threefold smaller volume (P < 0.025) and a significant reduction of the mitotic index and of PCNA expression. Growth of A2058 cells in vivo was not affected by treatment with the p16-mimicking peptide. Our results demonstrate that p16-mimicking peptides can induce apoptosis in vitro and that can inhibit tumor growth in vivo in p16-defective, pRb-expressing human melanoma cells, suggesting that p16-mimicking peptides can represent a promising tool for targeted therapy in selected cancer phenotypes. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)

Autore CNR

• GIUSEPPE STARACE (Unità di personale interno)
• ARMANDO FELSANI (Unità di personale interno)
• IGEA D'AGNANO (Persona)

Insieme di parole chiave

• Keywords of "In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ARMANDO FELSANI (Unità di personale interno)
• IGEA D'AGNANO (Persona)
• GIUSEPPE STARACE (Unità di personale interno)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of cellular physiology (Rivista)

Insieme di parole chiave di

• Keywords of "In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells." (Insieme di parole chiave)