Differential modulatory effect of NGF on MHC class I and class II expression in spinal cord cells of EAE rats. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Differential modulatory effect of NGF on MHC class I and class II expression in spinal cord cells of EAE rats. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Stampachiacchiere B.1, Aloe L.2 (2005)
  Differential modulatory effect of NGF on MHC class I and class II expression in spinal cord cells of EAE rats.
  in Journal of neuroimmunology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Stampachiacchiere B.1, Aloe L.2 (literal)

Pagina inizio

• 20 (literal)

Pagina fine

• 30 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor = 2.824 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 169 (literal)

Rivista

• Journal of neuroimmunology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Neurobiology and Molecular Medicine, Department of Neurobiology, National Research Council (CNR), Rome, Italy. (literal)

Titolo

• Differential modulatory effect of NGF on MHC class I and class II expression in spinal cord cells of EAE rats. (literal)

Abstract

• Nerve growth factor (NGF) undergoes significant changes in the central nervous system (CNS) of patients affected by multiple sclerosis (MS) and of rats with experimental allergic encephalomyelitis (EAE). The major histocompatibility complex (MCH) class I and class II antigens are molecules that play a pivotal role in these neuro-inflammatory disorders. The aim of this study was to investigate the role of NGF on MCH class I and class II antigens in spinal cords cells of EAE rats. It was found that the administration of NGF in EAE rats enhances MHC-I, IFN-gamma receptor and interferon regulatory factor-1 expression on the neurons but not in the glial cells, while NGF decreased MHC class II antigen in the glial cells. NGF administration into the brain of EAE rats has no effect on TNF-alpha expression. The present findings suggest that NGF may have a regulatory function in spinal cord cells during tissue inflammation. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR

• LUIGI ALOE (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Differential modulatory effect of NGF on MHC class I and class II expression in spinal cord cells of EAE rats." (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Funzioni del S.N./Neurotrofine (SV.P16.007.001) (Modulo)

Autore CNR di

• LUIGI ALOE (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of neuroimmunology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Differential modulatory effect of NGF on MHC class I and class II expression in spinal cord cells of EAE rats." (Insieme di parole chiave)