Effect of exercise on ovarian morphology and expression of nerve growth factor and alpha(1)- and beta(2)-adrenergic receptors in rats with steroid-induced polycystic ovaries. (Articolo in rivista)

Type
Label
  • Effect of exercise on ovarian morphology and expression of nerve growth factor and alpha(1)- and beta(2)-adrenergic receptors in rats with steroid-induced polycystic ovaries. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/j.1365-2826.2005.01378.x (literal)
Alternative label
  • Manni L.1,2; Cajander S.3; Lundeberg T.4; Naylor A.S.5; Aloe L.2; Holmang A.1; Jonsdottir I.H.5,6; Stener-Victorin E.1,7 (2005)
    Effect of exercise on ovarian morphology and expression of nerve growth factor and alpha(1)- and beta(2)-adrenergic receptors in rats with steroid-induced polycystic ovaries.
    in Journal of neuroendocrinology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Manni L.1,2; Cajander S.3; Lundeberg T.4; Naylor A.S.5; Aloe L.2; Holmang A.1; Jonsdottir I.H.5,6; Stener-Victorin E.1,7 (literal)
Pagina inizio
  • 846 (literal)
Pagina fine
  • 858 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Impact Factor = 2.974 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 17 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 12 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1 Neurobiology and Molecular Medicine Institute, National Research Council, Rome, Italy; 2 Cardiovascular Institute and Wallenberg Laboratory, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden; 3 Department of Pathology and Cytology, Akademiska Sjukhuset, Uppsala, Sweden; 4 Rehabilitation Medicine, Danderyds Hospital, Stockholm, Sweden; 5 Department of Physiology, Institute of Physiology and Pharmacology, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden; 6 Institute of Stress Medicine, Go¨ teborg, Sweden; 7 Department of Obstetrics and Gynaecology, Institute for the Health of Women and Children, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden (literal)
Titolo
  • Effect of exercise on ovarian morphology and expression of nerve growth factor and alpha(1)- and beta(2)-adrenergic receptors in rats with steroid-induced polycystic ovaries. (literal)
Abstract
  • Oestadiol valerate (EV)-induced polycystic ovaries (PCO) in rats cause anovulation and cystic ovarian morphology. Denervation of ovarian sympathetic nerves restores ovulatory disruption. In the present study, we determined whether 5 weeks of voluntary exercise influence ovarian morphology and the expression of sympathetic markers in the EV-induced PCO rat model. The effect of exercise on (i) ovarian morphology; (ii) mRNA and protein expression of nerve growth factor (NGF); and (iii) mRNA and number of ovarian-expressing cells for the NGF receptor (p75 neurotrophin receptor) and the alpha(1a)-, alpha(1b)-, alpha(1d)- and beta(2)-adrenergic receptors (ARs) in rats with EV-induced PCO was evaluated. PCO was induced by a single i.m. injection of EV, and controls were injected with oil alone in adult cycling rats. The rats were divided into four groups: (i) control (oil); (ii) exercise group (oil + exercise); (iii) a PCO group (EV); and (iv) a PCO exercise group (EV + exercise). The exercise and PCO exercise groups ran voluntarily for 5 weeks in computer-monitored wheels placed in the cages where they were housed. The results obtained indicated that ovarian morphology was almost normalised in the PCO exercise group; NGF mRNA and protein concentrations were normalised in the PCO exercise group; high numbers of NGF receptor expressing cells in PCO ovaries were lowered by exercise; and the number of immunopositive cells of the different AR subtypes were all reduced after exercise in the PCO group, except for the alpha(1b)- and beta(2)-AR whereas the mRNA levels were unaffected, indicating transcriptional regulation. In conclusion, our data indicate a beneficial effect of regular exercise, as a modulator of ovarian sympathetic innervation, in the prevention and treatment of human PCOS. (literal)
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