Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• De Angelis I.1,, Friggè G.2, Raimondi F.3, Stammati A.4, Zucco F.5, Caloni F.6 (2005)
  Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein.
  in Toxicon (Oxf.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• De Angelis I.1,, Friggè G.2, Raimondi F.3, Stammati A.4, Zucco F.5, Caloni F.6 (literal)

Pagina inizio

• 285 (literal)

Pagina fine

• 291 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Impact Factor = 1.862 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 45 (literal)

Rivista

• Toxicon (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1,4 = Department of Environment and Primary Prevention, Toxicity Mechanism Unit, Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, Italy; 2,3,6 = Department of Veterinary Sciences and Technologies for Food Safety, University of Milan, Milan, Italy; 5 = Neurobiology and Molecular Medicine Institute, CNR, Rome, Italy. (literal)

Titolo

• Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein. (literal)

Abstract

• The aim of the present paper is to evaluate the absorption of fumonisin B1 and its principal metabolite, aminopentol on a human intestinal model, Caco-2 cells, cultured on semi-permeable inserts, that reproduces the two different intestinal compartments: luminal (apical) and serosal (basolateral) side. Following separate exposure in apical and in basolateral compartments, aminopentol passage through the cell layer (in particular from basolateral to apical direction) was shown, while it was not observed for the parent compound. The different aminopentol distribution between the two compartments of the culture system, and its variation in presence of verapamil or probenecid (P-gp and MRP inhibitors respectively), strongly suggests the involvement of P-glycoprotein in the influx/efflux mechanisms of aminopentol in the intestinal cells, reducing its oral bioavailability. (literal)

Prodotto di

• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• MARIA FLAVIA ZUCCO (Persona)

Insieme di parole chiave

• Keywords of "Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA FLAVIA ZUCCO (Persona)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Meccanismi regolativi del Differenziamento e Oncogenesi (ME.P03.007.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Toxicon (Rivista)

Insieme di parole chiave di

• Keywords of "Absorption of fumonisin B1 and aminopentol on an in vitro model of intestinal epithelium; the role of P-glycoprotein." (Insieme di parole chiave)