Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation. (Articolo in rivista)

Type
Label
  • Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Alternative label
  • Camera P, da Silva JS, Griffiths G, Giuffrida MG, Ferrara L, Schubert V, Imarisio S, Silengo L, Dotti CG, Di Cunto F. (2003)
    Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation.
    in Nature cell biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Camera P, da Silva JS, Griffiths G, Giuffrida MG, Ferrara L, Schubert V, Imarisio S, Silengo L, Dotti CG, Di Cunto F. (literal)
Pagina inizio
  • 1071 (literal)
Pagina fine
  • 1078 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • Impact Factor 14.739 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Il lavoro riguarda l’identificazione di una specifica Rho-binding protein Citron-N a livello cerebrale. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Paola Camera1 *, Jorge Santos Da Silva2 *, Gareth Griffiths 3, Maria Gabriella Giuffrida 4, Luciana Ferrara1, Lorenzo Silengo1, Carlos G. Dotti2 † and Ferdinando Di Cunto 1 † 1 Dipartimento di Genetica, Biologia e Biochimica Università Degli Studi di Torino Via Santena, 5 bis, Torino, Italy 2 Cavalieri Ottolenghi Scientific Institute Università Degli Studi di Torino A.O. San Luigi Gonzaga Regione Gonzole 10, 10024 Orbassano (Torino), Italy 3 EMBL, Department of Cell Biology, Postfach 102209 Heidelberg D- 69012, Germany 4 Consiglio Nazionale delle Ricerche, Istituto Scienze Produzioni Alimentari, Bioindustry Park del Canavese, Colleretto Giacosa (Torino), Italy (literal)
Titolo
  • Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation. (literal)
Abstract
  • The actin cytoskeleton is best known for its role during cellular morphogenesis. However, other evidence suggests that actin is also crucial for the organization and dynamics of membrane organelles such as endosomes and the Golgi complex. As in morphogenesis, the Rho family of small GTPases are key mediators of organelle actin-driven events, although it is unclear how these ubiquitously distributed proteins are activated to regulate actin dynamics in an organelle-specific manner. Here we show that the brain-specific Rho-binding protein Citron-N is enriched at, and associates with, the Golgi apparatus of hippocampal neurons in culture. Suppression of the whole protein or expression of a mutant form lacking the Rho-binding activity results in dispersion of the Golgi apparatus. In contrast, high intracellular levels induce localized accumulation of RhoA and filamentous actin, protecting the Golgi from the rupture normally produced by actin depolymerization. Biochemical and functional analyses indicate that Citron-N controls actin locally by assembling together the Rho effector ROCK-II and the actin-binding, neuron-specific, protein Profilin-IIa (PIIa). Together with recent data on endosomal dynamics, our results highlight the importance of organelle-specific Rho modulators for actin-dependent organelle organization and dynamics. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it