Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid transfer protein allergen and is often without clinical expression (Articolo in rivista)

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  • Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid transfer protein allergen and is often without clinical expression (Articolo in rivista) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pastorello E.A.1, Pravettoni V.1,Farioli L.2, Rivolta F.1, Conti A.3, Ispano M.4, Fortunato D.3, Bengtsson A.5, Bianchi M.1 (2002)
    Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid transfer protein allergen and is often without clinical expression
    in Journal of allergy and clinical immunology
    (literal)
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  • Pastorello E.A.1, Pravettoni V.1,Farioli L.2, Rivolta F.1, Conti A.3, Ispano M.4, Fortunato D.3, Bengtsson A.5, Bianchi M.1 (literal)
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  • 310 (literal)
Pagina fine
  • 317 (literal)
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  • Impact Factor 5.506 (literal)
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  • 110 (literal)
Rivista
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  • Vi sono sempre maggiori evidenze che le allergie alimentari negli adulti possano derivare da sensibilizzazioni primarie ad allergeni respiratori. In questo lavoro sono stati studiati pazienti allergici alla pesca con anche IgE seriche specifiche per il polline di artemisia. Dopo aver individuato e caratterizzato i maggiori allergeni di artemisia e della pesca, mediante prove di inibizione dell'immunoblotting si è arrivati alla importante conclusione che i pazienti sensibilizzati solo alla Lipid Transfer Proteins di artemisia non presentano sindrome allergica orale ma possono avere manifestazioni cliniche per cross-reattività con il principale allergene della pesca, anch'esso una Lipid Transfer Protein. (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • 1 Allergy Centre, Ospedale Maggiore IRCCS, Milano; 2 UOOML, CEMOC, I.P.C., Milano; 3 CNR-ISPA, Torino 4 Divisione Bizzozzero, Ospedale Niguarda, Milano; 5 Pharmacia & Upjohn Diagnostic, Upsala, Svezia. (literal)
Titolo
  • Hypersensitivity to mugwort (Artemisia vulgaris) in patients with peach allergy is due to a common lipid transfer protein allergen and is often without clinical expression (literal)
Abstract
  • Background: The observation of mugwort-specific IgE antibodies in patients with peach allergy suggests that mugwort sensitization might play a role in sensitization to peach. Objective: We sought to study the clinical manifestations of mugwort hypersensitivity in patients with peach allergy, identify the common allergens, and evaluate their IgE cross-reactivity. Methods: Patients with oral allergy syndrome for peach and specific IgE antibodies to mugwort were investigated for respiratory symptoms during the mugwort season. Peach and mugwort allergens were identified by means of SDS-PAGE and IgE immunoblotting. Immunoblotting inhibition experiments were done to study cross-reactivity between peach and mugwort and other pollens. Results: Seventeen patients were studied, 10 with no seasonal respiratory symptoms and 7 with clear late summer respiratory symptoms. In IgE immunoblotting the 10 asymptomatic patients reacted only to a 9-kd allergen of both mugwort and peach, whereas the 7 patients with pollinosis reacted to other allergens. Ten patients with mugwort allergy, no history of allergy to peach, and negative results for peach specific IgE antibodies were also studied. The mugwort 9-kd protein was identified as a lipid transfer protein (LTP) homologous to peach LTP. Immunoblotting inhibition showed that IgE binding to the peach 9-kd band was totally inhibited by 4 µg of peach LTP but only by 400 µg of mugwort LTP, whereas 4 µg of both mugwort and peach LTP totally inhibited the mugwort immunoblotting. The results were similar with other pollens. Conclusions: Patients sensitized only to the 9-kd LTP of mugwort do not present hay fever symptoms, and this sensitization is a consequence of the peach sensitization. (literal)
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