http://www.cnr.it/ontology/cnr/individuo/prodotto/ID45984

Cellular adaptive response to chronic radiation exposure in interventional cardiologists (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Cellular adaptive response to chronic radiation exposure in interventional cardiologists (Articolo in rivista) (literal)

Anno

2012-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1093/eurheartj/ehr263 (literal)

Alternative label

Russo, Gian Luigi (3); Idolo, Tedesco (3); Russo, Maria (3); Cioppa, Angelo (2); Andreassi, Maria Grazia (1); Picano, Eugenio (1); (2012)
Cellular adaptive response to chronic radiation exposure in interventional cardiologists
in European heart journal
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Russo, Gian Luigi (3); Idolo, Tedesco (3); Russo, Maria (3); Cioppa, Angelo (2); Andreassi, Maria Grazia (1); Picano, Eugenio (1); (literal)

Pagina inizio

408 (literal)

Pagina fine

414 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

ID_PUMA: cnr.ifc/2011-A0-125. - First published online: cnr.ifc/2011-A0-125. - First published online: August 23, 2011. - Descrizione sintetica del prodotto: Abstract link: http://www.ncbi.nlm.nih.gov/pubmed/21862464. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

33 (literal)

Rivista

European heart journal (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

Aug 23. [Epub ahead of print] (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

Abstract link: http://www.ncbi.nlm.nih.gov/pubmed/21862464 (literal)

Note

PubMe (literal)
ISI Web of Science (WOS) (literal)
Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

(1) CNR-IFC, Pisa; (2) Clinica Montevergine, Mercogliano, Italy; (3) Institute of Food Sciences, National Research Council, Avellino, Italy (literal)

Titolo

Cellular adaptive response to chronic radiation exposure in interventional cardiologists (literal)

Abstract

Aims Invasive cardiologists are the most exposed to ionizing radiation among health professionals and show an increased rate of somatic DNA damage. To evaluate the effects of chronic low-dose exposure to ionizing radiation on redox state and apoptotic activation. Methods and results We enrolled 10 healthy exposed professionals (all interventional cardiologists, Group II, exposed: age = 38 ± 5 years) and 10 age- and gender-matched unexposed controls (Group I, non-exposed). Exposed subjects had a median exposure of 4 mSv/year (range 1-8) by film badge dosimetry (below lead apron). We measured reduced glutathione (GSH, a marker of antioxidant response) in erythrocytes and plasma generation of hydrogen peroxide (a marker of oxyradical stress) by ferrous oxidation-xylenol orange assay in plasma. In both groups, lymphocytes were isolated and caspase-3 activity (a marker of apoptotic response) measured at baseline and following 2 Gy in vitro irradiation. Exposed subjects showed a three-fold increase in hydrogen peroxide (Group I = 2.21 ± 1.03 vs. II = 6.51 ± 1.55 ¼M H(2)O(2) equivalents) and a 1.7-fold increase in GSH (I = 12.37 ± 1.22 vs. II = 20.61 ± 2.16 mM). Exposed subjects also showed higher values of caspase-3 activity, both at baseline and-more strikingly-following high-dose radiation challenge. Conclusion In interventional cardiologists, chronic exposure to low-dose radiation is associated with an altered redox balance mirrored by an increase in hydrogen peroxide and with two possibly adaptive cellular responses: (i) an enhanced antioxidant defence (increase in GSH, counteracting increased oxyradical stress) and (ii) an increased susceptibility to apoptotic induction which might efficiently remove genetically damaged cells. (literal)

Prodotto di