DNA is Wrapped by the Nuclear Aggregates of Polyamines - The Imaging Evidence (Articolo in rivista)

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Label
  • DNA is Wrapped by the Nuclear Aggregates of Polyamines - The Imaging Evidence (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Iacomino G., Picariello G., Sbrana F., Di Luccia A., Raiteri R, and D'Agostino L. (2011)
    DNA is Wrapped by the Nuclear Aggregates of Polyamines - The Imaging Evidence
    in Biomacromolecules; American Chemical Society, Washington (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Iacomino G., Picariello G., Sbrana F., Di Luccia A., Raiteri R, and D'Agostino L. (literal)
Pagina inizio
  • 1178 (literal)
Pagina fine
  • 1186 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://pubs.acs.org/doi/abs/10.1021/bm101478j?prevSearch=iacomino&searchHistoryKey= (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Istituto di Scienze dell’Alimentazione – CNR, Via Roma 64 – 83100 Avellino (Italy) 2 Dipartimento di Ingegneria Biofisica ed Elettronica - Università degli Studi di Genova, via all'Opera Pia 11a – 16145 Genova (Italy) 3 Dipartimento di Scienze degli Alimenti - Università degli Studi di Foggia, via Napoli 25 – 71122 Foggia (Italy) (literal)
Titolo
  • DNA is Wrapped by the Nuclear Aggregates of Polyamines - The Imaging Evidence (literal)
Abstract
  • In the cell nucleus, putrescine, spermidine and spermine self-assemble with phosphate ions to generate three forms of compounds, named nuclear aggregates of polyamines (NAPs), which may interact with DNA. In an in vitro setting mimicking the cell nucleus milieu, this molecular aggregation occurs within well-defined ratios. Structural and functional analogies exist between the in vitro NAPs (ivNAPs) and their extractive homologues. The present paper reports images of ivNAPs at different resolution levels. Independent of the DNA template, ivNAPs become hierarchically stacked to ultimately produce macroscopic filamentous structures. The ivNAP-DNA complexes arranged in long and repetitive structures that displayed the self-similar features of natural fractals when dehydrated onto glass slides. Atomic force microscopy showed that ivNAPs have a cyclic structure and dispose around the DNA in a tube-like arrangement. Overall, the images indicate that these aggregates envelope the genomic DNA, thus playing a crucial role in DNA compaction and functioning. (literal)
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