Adaptive and innate immune responses in Coeliac Disease (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Adaptive and innate immune responses in Coeliac Disease (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Alternative label

• Gianfrani C; Auricchio S; Troncone R. (2005)
  Adaptive and innate immune responses in Coeliac Disease
  in Immunology letters
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Gianfrani C; Auricchio S; Troncone R. (literal)

Pagina inizio

• 141 (literal)

Pagina fine

• 145 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 99 (literal)

Rivista

• Immunology letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Food Science and Technology, CNR, Avellino, Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy (literal)

Titolo

• Adaptive and innate immune responses in Coeliac Disease (literal)

Abstract

• Celiac disease (CD) is a complex small intestinal disorder due to a dysregulated immune response to wheat gliadin and related proteins which leads to a small intestinal enteropathy. It is generally accepted that CD is a T-cell mediated disease, in which, gliadin derived peptides, either in native form or deamidated by tissue transglutaminase, activate lamina propria infiltrating T lymphocytes which release proinflammatory cytokines. Recent studies indicate that gliadin contains also peptides able to activate an innate immune response. In particular, they induce a selective expansion of IEL, particularly TCR?/?+ and CD8 + TCR ?/?+ lymphocytes bearing the CD94 NK receptor, as well as a strong epithelial expression of MICA molecules which interact with NKG2D receptor expressed on TCR?/?+ and NK cells. Most of the events of innate immune activation events are inhibited by antibodies neutralizing IL-15, thus confirming the key role of this cytokine as a mediator of intestinal mucosa damage induced by ingestion of gliadin. It remains to be established to what extent the ability of gliadin peptides to activate innate immunity relates to other biological properties exerted not only on celiac cells and tissues; the specificity of celiac patients is probably related to their genetic make up. (literal)

Prodotto di

• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Bioassay cellulari per l’analisi della proprietà immunostimolanti degli alimenti (AG.P05.005.008) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• CARMELA GIANFRANI (Unità di personale interno)
• Riccardo Troncone (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Bioassay cellulari per l’analisi della proprietà immunostimolanti degli alimenti (AG.P05.005.008) (Modulo)

Autore CNR di

• CARMELA GIANFRANI (Unità di personale interno)
• Riccardo Troncone (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Immunology letters (Rivista)