Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity. (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.imlet.2008.04.006 (literal)

Alternative label

• D'Arienzo R; Maurano F; Luongo M; Mazzarella G; Stefanile R; Troncone R; Auricchio S; Ricca E; David C; Rossi M. (2008)
  Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity.
  in Immunology letters
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• D'Arienzo R; Maurano F; Luongo M; Mazzarella G; Stefanile R; Troncone R; Auricchio S; Ricca E; David C; Rossi M. (literal)

Pagina inizio

• 335 (literal)

Pagina fine

• 341 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 74 (literal)

Rivista

• Immunology letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Food Sciences, CNR, Avellino, Italy European Laboratory for Investigation of Food Induced Diseases, Department of Pediatrics University ‘‘Federico II’’ of Naples, Naples, Italy Dipartimento di Biologia Strutturale e Funzionale, Università Federico II, Napoli, Italy Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA (literal)

Titolo

• Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity. (literal)

Abstract

• Probiotic strains have been reported to exert immunomodulatory activities in the gut-associated lymphoid tissue. In this study we explored the effect of Lactobacillus casei in transgenic mice expressing the human DQ8 heterodimer, a HLA molecule linked to Celiac Disease (CD). DQ8 mice, mucosally immunized with the gluten component gliadin, mounted an intestinal Th1-like response as observed in CD, without developing enteropathy. Co-administration of L. casei in sensitized mice specifically enhanced the gliadin-specific response mediated by CD4(+) T cells. Notably, both a strong increase of the gliadin-specific IFNgamma expression and a pro-inflammatory polarization of the cytokine milieu in the small intestinal mucosa were associated to the presence of the probiotic strain. However, this condition did not bring on any mucosal alteration. These findings suggest that the gliadin-specific enteropathy is not merely related to the HLA DQ8-restricted massive production of IFNgamma, but additional parameters are involved. Moreover, our data imply that the intrinsic adjuvanticity of L. casei can be exploited to further enhance both mucosal and systemic T cell-mediated responses. (literal)

Prodotto di

• Tecnologie, Tracciabilità e Sicurezza degli Alimenti (AG.P05.004.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• FRANCESCO MAURANO (Persona)
• GIUSEPPE MAZZARELLA (Unità di personale interno)
• DIOMIRA LUONGO (Persona)
• MAURO ROSSI (Unità di personale interno)
• Rosita Stefanile (Persona)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Tecnologie, Tracciabilità e Sicurezza degli Alimenti (AG.P05.004.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)

Autore CNR di

• MAURO ROSSI (Unità di personale interno)
• GIUSEPPE MAZZARELLA (Unità di personale interno)
• FRANCESCO MAURANO (Persona)
• Rosita Stefanile (Persona)
• DIOMIRA LUONGO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Immunology letters (Rivista)