http://www.cnr.it/ontology/cnr/individuo/prodotto/ID45802
Gliadin regulates the NK-dendritic cell cross-talk by HLA-E surface stabilization. (Articolo in rivista)
- Type
- Label
- Gliadin regulates the NK-dendritic cell cross-talk by HLA-E surface stabilization. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
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- Terrazzano G; Sica M; Gianfrani C; Mazzarella G; Maurano F; De Giulio B; de Saint-Mezard S; Zanzi D; Maiuri L; Londei M; Jabri B; Troncone R; Auricchio S; Zappacosta S; Carbone E. (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Department of Cellular and Molecular Biology and Pathology, University Federico II, Naples, Italy;
Institute of Food Science and Technology, Consiglio Nazionale delle Ricerche, Avellino, Italy;
Department of Pathology, University of Chicago, Chicago, IL 60607;
Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy;
Institute of Child Health, University College London, London, United Kingdom;
?Department of Experimental and Clinical Medicine University \"Magna Graecia,\" Catanzaro, Italy;
Research Center for Studies of Integrative Recognition in the Immune System, Karolinska Institutet, Stockholm, Sweden;
Microbiology and Tumorbiology Centre, Karolinska Institutet, Stockholm, Sweden (literal)
- Titolo
- Gliadin regulates the NK-dendritic cell cross-talk by HLA-E surface stabilization. (literal)
- Abstract
- We analyzed the autologous NK cell interaction with gliadin-presenting dendritic cells. Gliadin is the known Ag priming the celiac
disease (CD) pathogenesis. We demonstrate that gliadin prevents immature dendritic cells (iDCs) elimination by NK cells. Furthermore,
cooperation between human NK cells-iDCs and T cells increases IFN-? production of anti-gliadin immune response.
Gliadin fractions were analyzed for their capability to stabilize HLA-E molecules. The ? and ? fractions conferred the protection
from NK cell lysis to iDCs and increased their HLA-E expression. Gliadin pancreatic enzyme digest and a peptide derived from
gliadin ? increased HLA-E levels on murine RMA-S/HLA-E-transfected cells. Analysis of HLA-E expression in the small intestinal
mucosa of gluten-containing diet celiac patients and organ culture experiments confirmed the in vitro data. (literal)
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