http://www.cnr.it/ontology/cnr/individuo/prodotto/ID45723
Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. (Articolo in rivista)
- Type
- Label
- Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. (Articolo in rivista) (literal)
- Anno
- 2007-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s00109-007-0192-3 (literal)
- Alternative label
D'Argenio G, Petrosino S, Gianfrani C, Valenti M, Scaglione G, Grandone I, Nigam S, Sorrentini I, Mazzarella G, Di Marzo V. (2007)
Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats.
in Journal of molecular medicine (Berl., Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- D'Argenio G, Petrosino S, Gianfrani C, Valenti M, Scaglione G, Grandone I, Nigam S, Sorrentini I, Mazzarella G, Di Marzo V. (literal)
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- Pagina fine
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- Rivista
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- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- G. D'Argenio : I. Grandone
Dipartimento di Gastroenterologia,
Università di Napoli \"Federico II\",
Naples, Italy
S. Petrosino : M. Valenti : V. Di Marzo (*)
Endocannabinoid Research Group,
Institute of Biomolecular Chemistry,
Consiglio Nazionale delle Ricerche,
Pozzuoli, Naples, Italy
e-mail: vdimarzo@icmib.na.cnr.it
S. Petrosino
Dipartimento di Scienze Farmaceutiche,
Università degli Studi di Salerno,
Fisciano, Italy
C. Gianfrani : G. Mazzarella
Istituto di Scienze dell'Alimentazione,
Consiglio Nazionale delle Ricerche,
Avellino, Italy
G. Scaglione : I. Sorrentini
Gastroenterologia, A.O. \"Rummo\",
Benevento, Italy
S. Nigam
Eicosanoid & Lipid Research Division,
and Centre for Experimental Gynecology & Breast Research,
University-Klinikum Benjamin Franklin,
Free University Berlin,
Berlin, Germany
GIUSEPPE D'ARGENIO
received his Ph.D. in
Gastroenterological Sciences
from the University of Rome \"la
Sapienza.\" After a postdoctoral
fellowship with Prof. Fevery,
University of Leuven, Belgium
and an Assistant Professorship
at the University of Naples,
Italy, in Enzymology, he is
presently leading the Laboratory
for Research in Gastroenterology,
Department of Clinical and
Experimental Medicine at the
School of Medicine, Federico II
University of Naples, Italy. His
research interests include
enzymology, repairing process,
and cell biology in gut
inflammation.
VINCENZO DI MARZO
did a first degree in Chemistry
at the University of Naples
and completed a Ph.D. in
biochemistry and molecular
pharmacology at the Imperial
College, London, UK, in 1988.
He is Research Director at the
Institute of Biomolecular
Chemistry of the National
Research Council in Pozzuoli,
Naples, Italy, and Coordinator of
the Endocannabinoid Research
Group in the Naples Region. His
research interests include the
biosynthesis, metabolism, and
physiopathological role of
endocannabinoids and bioactive
fatty acid (literal)
- Titolo
- Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats. (literal)
- Abstract
- The endocannabinoid system is upregulated in both human inflammatory bowel diseases and experimental models of colitis. In this study, we investigated whether this upregulation is a marker also of celiac disease-induced atrophy. The levels of the cannabinoid CB(1) receptor, of the endocannabinoids, anandamide, and 2-arachidonoyl-glycerol (2-AG), and of the anti-inflammatory mediator palmitoylethanolamide (PEA) were analyzed in bioptic samples from the duodenal mucosa of celiac patients at first diagnosis assessed by the determination of antiendomysial antibodies and histological examination. Samples were analyzed during the active phase of atrophy and after remission and compared to control samples from non-celiac patients. The levels of anandamide and PEA were significantly elevated (approx. 2- and 1.8-fold, respectively) in active celiac patients and so were those of CB(1) receptors. Anandamide levels returned to normal after remission with a gluten-free diet. We also analyzed endocannabinoid and PEA levels in the jejunum of rats 2, 3, and 7 days after treatment with methotrexate, which causes inflammatory features (assessed by histopathological analyses and myeloperoxidase activity) similar to those of celiac patients. In both muscle/serosa and mucosa layers, the levels of anandamide, 2-AG, and PEA peaked 3 days after treatment and returned to basal levels at remission, 7 days after treatment. Thus, intestinal endocannabinoid levels peak with atrophy and regress with remission in both celiac patients and methotrexate-treated rats. The latter might be used as a model to study the role of the endocannabinoid system in celiac disease. (literal)
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