Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheat. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheat. (Articolo in rivista) (literal)

Anno

• 2005-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00125-005-1718-2 (literal)

Alternative label

• Maurano F., Mazzarella G., Luongo D., Stefanile R., D'Arienzo R., Rossi M., Auricchio S., Troncone R. (2005)
  Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheat.
  in Diabetologia (Berl.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Maurano F., Mazzarella G., Luongo D., Stefanile R., D'Arienzo R., Rossi M., Auricchio S., Troncone R. (literal)

Pagina inizio

• 931 (literal)

Pagina fine

• 937 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 48 (literal)

Rivista

• Diabetologia (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Scienze dell'Alimentazione, CNR, Avellino, Italia Department of Pediatrics, European Laboratory for the Investigation of Food Induced Diseases-ELFID, University Federico II, Naples, Italy. (literal)

Titolo

• Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheat. (literal)

Abstract

• AIMS/HYPOTHESIS: A deranged mucosal immune response and dietary factors may play an important role in the pathogenesis of type 1 diabetes. The aims of our work were to look for the presence of small intestinal enteropathy in non-obese diabetic (NOD) mice in relation to the presence of wheat proteins in the diet, and to assess their role in the risk of developing diabetes. METHODS: Female NOD mice were fed a standard or gluten-free diet or a gluten-free diet with the addition of wheat proteins (MGFD). Small intestine architecture, intraepithelial CD3(+) infiltration, epithelial expression of H2-IA, mRNA for IFN-gamma and IL-4 were assessed. RESULTS: NOD mice fed a standard diet showed reduced villous height, increased intraepithelial infiltration by CD3(+) cells and enhanced expression of H2-IA and IFN-gamma mRNA when compared with mice on the gluten-free diet. The cumulative diabetes incidence at 43 weeks of age was 65% in the latter and 97% in the former (p<0.01). Mice on MGFD also showed increased epithelial infiltration and a higher incidence of diabetes. CONCLUSIONS/INTERPRETATION: Mice fed a wheat-containing diet showed a higher incidence of diabetes, signs of small intestinal enteropathy and higher mucosal levels of proinflammatory cytokines. (literal)

Prodotto di

• Tecnologie, Tracciabilità e Sicurezza degli Alimenti (AG.P05.004.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)
• Institute of food sciences (ISA) (Istituto)

Autore CNR

• DIOMIRA LUONGO (Persona)
• GIUSEPPE MAZZARELLA (Unità di personale interno)
• Rosita Stefanile (Persona)
• Rossana D'Arienzo (Persona)
• FRANCESCO MAURANO (Persona)
• MAURO ROSSI (Unità di personale interno)

Incoming links:

Prodotto

• Institute of food sciences (ISA) (Istituto)
• Tecnologie, Tracciabilità e Sicurezza degli Alimenti (AG.P05.004.001) (Modulo)
• Alimenti e salute dell'uomo (AG.P05.005.001) (Modulo)

Autore CNR di

• MAURO ROSSI (Unità di personale interno)
• GIUSEPPE MAZZARELLA (Unità di personale interno)
• FRANCESCO MAURANO (Persona)
• Rosita Stefanile (Persona)
• DIOMIRA LUONGO (Persona)
• Rossana D'Arienzo (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetologia (Rivista)