Altered plasma nerve growth factor-like immunoreactivity and nerve growth factor-receptor expression in human old age (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Altered plasma nerve growth factor-like immunoreactivity and nerve growth factor-receptor expression in human old age (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1159/000069170 (literal)

Alternative label

• Antonelli A., Bracci Laudiero L., Aloe L. (2003)
  Altered plasma nerve growth factor-like immunoreactivity and nerve growth factor-receptor expression in human old age
  in Gerontology (Basel)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Antonelli A., Bracci Laudiero L., Aloe L. (literal)

Pagina inizio

• 185 (literal)

Pagina fine

• 190 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• IF 2003 (ISI )= 1.6 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 49 (literal)

Rivista

• Gerontology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• I.F. 2002 = 1,418 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Neurobiology and Molecular nedicine, CNR, Rome Italy (literal)

Titolo

• Altered plasma nerve growth factor-like immunoreactivity and nerve growth factor-receptor expression in human old age (literal)

Abstract

• BACKGROUND: Nerve growth factor (NGF), discovered because of its action on cells in the peripheral and the central nervous system, is now known to act also on immune cells in developing and adult subjects. Whether peripheral lymphocytes of aged subjects are responsive to this molecule is less clear. OBJECTIVE: Aim of our study was to investigate whether or not plasma NGF undergoes any significant changes during aging and whether or not NGF receptors on peripheral lymphocytes are affected in old subjects. METHODS: To address these questions, we used RT-PCR, immunohistochemistry, and immunoenzymatic analysis to evaluate the expression of NGF receptors in human peripheral lymphocytes and NGF-like immunoreactivity. RESULTS: These results revealed a low amount of NGF in the plasma of old subjects associated with a reduced expression of mRNA for NGF receptor trkA in peripheral lymphocytes. They also showed elevated levels of circulating interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) in the bloodstream of adult and aged subjects. CONCLUSION: Our data indicate that peripheral lymphocytes are targets for circulating NGF and suggest that changes in NGF-receptor expression on lymphocytes might be potential marker for aging lymphocytes. Copyright 2003 S. Karger AG, Basel (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• LUIGI ALOE (Unità di personale interno)
• LUISA BRACCI LAUDIERO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Altered plasma nerve growth factor-like immunoreactivity and nerve growth factor-receptor expression in human old age" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• LUISA BRACCI LAUDIERO (Unità di personale interno)
• LUIGI ALOE (Unità di personale interno)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Gerontology (Rivista)

Insieme di parole chiave di

• Keywords of "Altered plasma nerve growth factor-like immunoreactivity and nerve growth factor-receptor expression in human old age" (Insieme di parole chiave)