Gluten sensitivity in a subset of children with insulin dependent diabetes mellitus. (Articolo in rivista)

Type
Label
  • Gluten sensitivity in a subset of children with insulin dependent diabetes mellitus. (Articolo in rivista) (literal)
Anno
  • 2003-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/S0002-9270(02)06023-9 (literal)
Alternative label
  • Troncone R, Franzese A, Mazzarella G, Paparo F, Auricchio R, Coto I, Mayer M, Greco L. (2003)
    Gluten sensitivity in a subset of children with insulin dependent diabetes mellitus.
    in The American journal of gastroenterology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Troncone R, Franzese A, Mazzarella G, Paparo F, Auricchio R, Coto I, Mayer M, Greco L. (literal)
Pagina inizio
  • 590 (literal)
Pagina fine
  • 595 (literal)
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  • 11 (literal)
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  • 98-3 (literal)
Rivista
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  • Diversi studi hanno dimostrato la stretta associazione tra diabete e celiachia. Il challenge rettale con glutine viene utilizzato normalmente per saggiare la risposta immune mucosale specifica locale alla gliadina nella malattia celiaca. Lo scopo del nostro lavoro è stato quello di testare la risposta immune mucosale alla gliadina nei bambini con diabete mellito insulino-dipendente (DMID) utilizzando il challenge rettale con gliadina. Approssimativamente il 20% dei bambini con DMID hanno reagito all'instillazione rettale di gliadina; infatti, mediante tecnica immunoistochimica tali pazienti presentavano una mucosa rettale con un aumento significativo dei linfociti T, sia a/b che g/d, intraepiteliali Tali dati suggeriscono che una significativa proporzione di soggetti con DMID presentano una abnormale risposta immune mucosale alla gliadina. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • R Troncone, A Franzese, , F Paparo, R Auricchio,I Coto, M Mayer, L Greco Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University “Federico II,” Naples;Giuseppe Mazzarella Institute of Food Sciences and Technology, Consiglio Nazionale delle Richerche, Avellino, Italy (literal)
Titolo
  • Gluten sensitivity in a subset of children with insulin dependent diabetes mellitus. (literal)
Abstract
  • OBJECTIVES: The association between celiac disease and insulin dependent diabetes mellitus (IDDM) is well established. Rectal gluten challenge has been used in patients with celiac disease and in first degree relatives as a tool to assess the mucosal immune response to gluten. The aim of this study was to assess the mucosal immune response to gluten in IDDM children by rectal gluten challenge. METHODS: Rectal biopsy specimens were obtained from 19 children with IDDM before and 6 h after rectal challenge with 2 g of a peptic tryptic digest of gliadin. A total of 16 treated celiac patients and 10 control subjects were also investigated. Epithelium and lamina propria CD3(+) and gamma delta(+) lymphocytes were counted with reference to a standard reference area of muscularis mucosae (10(4) microm(2)). RESULTS: After a local instillation of gliadin, a significant (>mean + 1 SD) percentage increment of lamina propria and epithelium CD3(+) and of lamina propria and epithelium gamma delta(+) lymphocytes was observed in five IDDM children, as compared to 11 and 13 celiac patients and one and two controls, respectively. A discriminant analysis allowed correct classification of 100% of patients with celiac disease and controls. The same analysis classified four of 19 IDDM children in the group of celiac patients. The positivity was associated with normal serology (antigliadin antibody, antiendomysial antibody, and antitissue transglutaminase antibodies) and a morphologically normal jejunal mucosa. All four patients had HLA-DQ alleles associated with celiac disease. CONCLUSIONS: Approximately 20% of IDDM children react to rectal instillation of gliadin. Long term follow-up is necessary to establish whether these subjects are at increased risk for developing celiac disease. (literal)
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