Up regulation of P2X2 and P2X4 receptors during ischemic cell death: prevention by P2 antagonists. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Up regulation of P2X2 and P2X4 receptors during ischemic cell death: prevention by P2 antagonists. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0306-4522(03)00228-8 (literal)

Alternative label

• Cavaliere F., Florenzano F., Amadio S., Fusco F.R, Viscomi M.T., D'Ambrosi N., Vacca F., Sancesario G., Bernardi G., Molinari M., Volonté C. (2003)
  Up regulation of P2X2 and P2X4 receptors during ischemic cell death: prevention by P2 antagonists.
  in Neuroscience
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cavaliere F., Florenzano F., Amadio S., Fusco F.R, Viscomi M.T., D'Ambrosi N., Vacca F., Sancesario G., Bernardi G., Molinari M., Volonté C. (literal)

Pagina inizio

• 85 (literal)

Pagina fine

• 98 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• IF =3.601 SCI-JCR 2003 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 120 (literal)

Rivista

• Neuroscience (Rivista)

Note

• Scopu (literal)
• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, FSL, Univrsità Toer Vergata (literal)

Titolo

• Up regulation of P2X2 and P2X4 receptors during ischemic cell death: prevention by P2 antagonists. (literal)

Abstract

• In the present work we examined the involvement of selected P2X receptors for extracellular ATP in the onset of neuronal cell death caused by glucose/oxygen deprivation. The in vitro studies of organotypic cultures from hippocam-pus evidenced that P2X2 and P2X4 were up-regulated by glucose/oxygen deprivation. Moreover, we showed that isch-emic conditions induced specific neuronal loss not only in hippocampal, but also in cortical and striatal organotypic cultures and the P2 receptor antagonists basilen blue and suramin prevented these detrimental effects. In the in vivo experiments we confirmed the induction of P2X receptors in the hippocampus of gerbils subjected to bilateral common carotid occlusion. In particular, P2X2 and P2X4 proteins be-came significantly up-regulated, although to different extent and in different cellular phenotypes. The induction was con-fined to the pyramidal cell layer of the CA1 subfield and to the transition zone of the CA2 subfield and it was coincident with the area of neuronal damage. P2X2 was expressed in neuro-nal cell bodies and fibers in the CA1 pyramidal cell layer and in the strata oriens and radiatum. Intense P2X4 immunofluo-rescence was localized to microglia cells. Our results indicate a direct involvement of P2X receptors in the mechanisms sustaining cell death evoked by metabo-lism impairment and suggest the use of selected P2 antago-nists as effective neuroprotecting agents. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• CINZIA VOLONTE' (Unità di personale interno)

Incoming links:

Autore CNR di

• CINZIA VOLONTE' (Unità di personale interno)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience (Rivista)