Identification of six putative novel human papillomaviruses (HPV) and characterization of candidate HPV type 87. (Articolo in rivista)

Type
Label
  • Identification of six putative novel human papillomaviruses (HPV) and characterization of candidate HPV type 87. (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • Menzo S. 1, Monachetti A. 2, Trozzi C. 3, Ciavattini A. 4, Carloni G. 5, Varaldo P.E. 6, Clementi M. 7 (2001)
    Identification of six putative novel human papillomaviruses (HPV) and characterization of candidate HPV type 87.
    in Journal of virology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Menzo S. 1, Monachetti A. 2, Trozzi C. 3, Ciavattini A. 4, Carloni G. 5, Varaldo P.E. 6, Clementi M. 7 (literal)
Pagina inizio
  • 11913 (literal)
Pagina fine
  • 11919 (literal)
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  • Impact Factor: 5.622 L'analisi filogenetica documenta che il genoma dell'HPV87 è associato con gli HPV del gruppo A3 che sono stati clonati e sequenziati interamente insieme ad altri nuovi genotipi, due dei quali sono descritti in questo lavoro. (literal)
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  • 75 (literal)
Rivista
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  • Vengono identificati 6 nuovi Papillomavirus da campioni clinici. Dati clinici, molecolari ed esperimenti condotti mediante espressione in colture di tessuto delle oncoproteine E6 ed E7 clonate indicano che il loro potere trasformate è di grado intermedio. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 7 UNI Trieste, 5 INMM CNR, 1,2,3,4,6 UNI Ancona, (literal)
Titolo
  • Identification of six putative novel human papillomaviruses (HPV) and characterization of candidate HPV type 87. (literal)
Abstract
  • Six putative novel human papillomavirus (HPV) types were detected by using general primers for a conserved L1 HPV region in patients examined in gynecologic centers. One of the isolates, detected in samples from 4 patients with koilocytic atypia at cervical cytology (3 of whom were also infected with human immunodeficiency virus type 1), was completely sequenced, identified as a new HPV genotype, and designated candidate HPV87 (candHPV87) by the Reference Center for Human Papillomavirus. candHPV87 shows the classic HPV genome organization and the absence of a functional E5 coding region. Phylogenetic analysis documented that the candHPV87 genome clusters within the A3 group of HPVs, together with HPV61, HPV72, HPV83, HPV84 and candHPV86, which have been completely sequenced, and a number of other putative novel genotypes (two of which are described in this work), which have been partially characterized. To address the growth-enhancing potential of candHPV87, the E6 and E7 putative coding regions were cloned and expressed in tissue cultures. The data indicate that both proteins stimulate cell division in tissue cultures more than those of low-risk HPVs, though not as much as those of HPV16. Taken together, the clinical, molecular, and biological data suggest that the novel papillomavirus characterized in the present study is a low- to intermediate-risk HPV. (literal)
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