THYMOSIN a1 IN COMBINATION WITH CYTOKINES AND CHEMOTHERAPY FOR THE TREATMENT OF CANCER. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• THYMOSIN a1 IN COMBINATION WITH CYTOKINES AND CHEMOTHERAPY FOR THE TREATMENT OF CANCER. (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Garaci E. (a), Pica F. (a), Sinibaldi-Vallebona P. (a), Pierimarchi P. (b), Mastino A. (a), Matteucci C. (a), Rasi G (b). (2003)
  THYMOSIN a1 IN COMBINATION WITH CYTOKINES AND CHEMOTHERAPY FOR THE TREATMENT OF CANCER.
  in International immunopharmacology (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Garaci E. (a), Pica F. (a), Sinibaldi-Vallebona P. (a), Pierimarchi P. (b), Mastino A. (a), Matteucci C. (a), Rasi G (b). (literal)

Pagina inizio

• 1145 (literal)

Pagina fine

• 1150 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3 (literal)

Rivista

• International immunopharmacology (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a) Dipartimento Medicina Sperimentale e Scienze Biochimiche, Università di Tor Vergata, Via Montpellier, 1-00133 Rome, Italy b) Istituto di Neurobiologia e Medicina Molecolare, Sezione di Medicina Molecolare, CNR-Via Fosso del Cavaliere, 100-00133 Rome, Italy (literal)

Titolo

• THYMOSIN a1 IN COMBINATION WITH CYTOKINES AND CHEMOTHERAPY FOR THE TREATMENT OF CANCER. (literal)

Abstract

• Multiple therapeutic approaches have been tested in different experimental tumour models and in human cancers. Most part of them are based on the hypothesis that the inhibition of tumour growth requires a strong immune response in which a main role is played by CTLs. It is known, however, that an efficient CTL response requires expression of tumour antigens, MHC class I surface molecules presentation, expression of different co-stimulatory molecules and a sustained generation and proliferation of specific cytotoxic CD8+ cells with an efficient CD4+ cooperation.In this context, our group has extensively explored a protocol of combined therapy consisting of the use of chemotherapeutic agents associated with thymosin alpha 1 (Talpha 1) and different cytokines, whose efficacy has been demonstrated in experimental models as well as in human cancers. In this manuscript, the main data supporting a pivotal role of Talpha 1 in such combination protocols are reviewed. In particular, a special mention of the molecular mechanisms underlying the effects of Talpha 1 on immune effector cells as well as on target tumour cells is provided. These data contribute to explain the mechanism of action of Talpha 1, when used in combination therapy, for the treatment of cancer and provide new insights in predicting further possible applications of this peptide in other pathological conditions. (literal)

Prodotto di

• Patologie infettive, infiammatorie e degenerative (ME.P04.005.001) (Modulo)
• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Ricerca traslazionale ed outcome nelle patologie infiammatorie e degenerative (ME.P04.009.001) (Modulo)

Autore CNR

• GUIDO RASI (Unità di personale esterno)
• PASQUALE PIERIMARCHI (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)
• Patologie infettive, infiammatorie e degenerative (ME.P04.005.001) (Modulo)
• Ricerca traslazionale ed outcome nelle patologie infiammatorie e degenerative (ME.P04.009.001) (Modulo)

Autore CNR di

• PASQUALE PIERIMARCHI (Unità di personale interno)
• GUIDO RASI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• International immunopharmacology (Rivista)