http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4491
Stress alters vascular-endothelial growth factor expression in rat arteries: Role of nerve growth factor. (Articolo in rivista)
- Type
- Label
- Stress alters vascular-endothelial growth factor expression in rat arteries: Role of nerve growth factor. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1007/s00395-004-0502-7 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Manni L.1; Antonelli A.2; Costa N.3; Aloe L .4 (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
- Impact Factor = 5.9 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- 1,2,4 = Institute of Neurobiology and Molecular Medicine, Section of Neurobiology, CNR, Viale Marx, 43/15, 00137 Roma, Italy;
3 = Università degli Studi Magna Grecia, Catanzaro, Italy. (literal)
- Titolo
- Stress alters vascular-endothelial growth factor expression in rat arteries: Role of nerve growth factor. (literal)
- Abstract
- The aim of this study was to investigate the role of stress and nerve growth factor (NGF) on the expression of vascularendothelial growth factor (VEGF) and NGF highaffinity receptor (tyrosine kinase A, TrKA) in the ascending and abdominal aorta.
Adult male rats were exposed to immobilization stress for one hour or injected with purified murine NGF. Four hours after treatments, rats were sacrificed and VEGF, NGF and TrkA expression in ascending and abdominal aorta evaluated. The effects of antiNGF treatment on arterial VEGF expression and on stressinduced arterial cell proliferation were also studied in control and stressed rats.
The data indicated that both stress and NGF injection induced a rapid increase of arterial VEGF associated with an elevated level of NGF and TrkA in arterial tissues. Blocking NGF action by neutralizing NGFantibodies, results in downregulation of stressinduced VEGF expression by arteries and in the blockade of stressinduced proliferation of cells from the arterial wall.
Overall our data demonstrated that NGF is involved in the regulation of VEGF and in cardiac vessels response after emotional stress. (literal)
- Prodotto di
- Autore CNR
- Insieme di parole chiave
Incoming links:
- Prodotto
- Autore CNR di
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
- Insieme di parole chiave di