Vaccination with a synthetic nonapeptide expressed in human tumors prevents colorectal cancer liver metastases in syngeneic rats (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Vaccination with a synthetic nonapeptide expressed in human tumors prevents colorectal cancer liver metastases in syngeneic rats (Articolo in rivista) (literal)

Anno

• 2004-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/ijc.20063 (literal)

Alternative label

• Sinibaldi V.P.1; Rasi G.2; Pierimarchi P.2; Bernard P.2; Guarino E.2; Guadagni F.3; Garaci E.1 (2004)
  Vaccination with a synthetic nonapeptide expressed in human tumors prevents colorectal cancer liver metastases in syngeneic rats
  in International journal of cancer (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sinibaldi V.P.1; Rasi G.2; Pierimarchi P.2; Bernard P.2; Guarino E.2; Guadagni F.3; Garaci E.1 (literal)

Pagina inizio

• 70 (literal)

Pagina fine

• 75 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 110 (literal)

Rivista

• International journal of cancer (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 Department of Experimental Medicine and Biochemical Sciences , University of Rome Tor Vergata, Rome, Italy; 2 Istituto di neurobiologia e medicina molecolare, CNR, Rome, Italy 3 Laboratory of Clinical Pathology, Regina Elena Cancer Institute, Rome, Italy (literal)

Titolo

• Vaccination with a synthetic nonapeptide expressed in human tumors prevents colorectal cancer liver metastases in syngeneic rats (literal)

Abstract

• In previous studies, the antigen CSH-275 (RTNKEASIC) was found expressed in tissue specimens from colorectal cancer but not in normal colonic mucosa. It was also naturally expressed in the DHD-K12 experimental colorectal cancer in BDIX rats. In this study, we describe the effect of vaccination with the synthetic nonapeptide CSH-275 in preventing tumor growth in a model closely mimicking the clinical situation of liver metastases, after surgical resection of primary colorectal cancer. A vaccination protocol using CSH-275, conjugated with complete or incomplete Freund's adjuvant, was carried out to determine the effect in preventing the progression of liver metastases induced by DHD-K12 cells injected in the splenic vein (preventive vaccine). An additional vaccination procedure was carried out to determine the effect on s.c. tumor growth (therapeutic vaccine). A significant improvement in survival along with the prevention of liver metastases formation and reduced growth of s.c. tumor were observed. CSH-275 vaccination resulted in a significant increase in CTL activity against autologous DHD-K12 cells in DHD-K12 tumor-bearing rats and the generation of a CTL response against DHD-K12 cells in DHD-K12 naive rats. Vaccination also induced massive infiltration of CD8(+) cells in tumor. These results demonstrate that CSH-275 is a new molecular target for colorectal cancer immunotherapy; it is also an excellent candidate for preclinical studies because it is naturally expressed on tumors in a fully competent syngeneic animal, which reproduces the clinical pattern of cancer progression. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• paola sinibaldi vallebona (Persona)
• GUIDO RASI (Unità di personale esterno)
• PASQUALE PIERIMARCHI (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR di

• PASQUALE PIERIMARCHI (Unità di personale interno)
• GUIDO RASI (Unità di personale esterno)
• paola sinibaldi vallebona (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• International journal of cancer (Rivista)