Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms. (Articolo in rivista)

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  • Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms. (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/sj.cdd.4401663 (literal)
Alternative label
  • T Parasassi (1); R Brunelli (1,2); L Bracci-Laudiero (1); G Greco (1); AC Gustafsson (3); EK Krasnowska (1); J Lundeberg (3); T Lundeberg (4); E Pittaluga (1); MC Romano (5); A Serafino (1) (2005)
    Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms.
    in Cell death and differentiation
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • T Parasassi (1); R Brunelli (1,2); L Bracci-Laudiero (1); G Greco (1); AC Gustafsson (3); EK Krasnowska (1); J Lundeberg (3); T Lundeberg (4); E Pittaluga (1); MC Romano (5); A Serafino (1) (literal)
Pagina inizio
  • 1285 (literal)
Pagina fine
  • 1296 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 12 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Note
  • PubMe (literal)
  • Google Scholar (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • (1) Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 15-43, 00137 Roma, Italy; (2) Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, Universita' di Roma La Sapienza, Viale del Policlinico 155, Roma, Italy; (3) Department of Biotechnology,KTH, Royal Institute of Technology, AlbaNova University Center, Roslagstullsbacken 21, Stockholm 10691 , Sweden; (4) Rehabilitation Medicine, Karolinska University Hospital, Stockholm 11776, Sweden; (5) Associazione Italiana Iniziativa Medicina Sociale, Corso Trieste 16, Roma 00185, Italy. (literal)
Titolo
  • Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms. (literal)
Abstract
  • We examined the morphological, biochemical and molecular outcome of a nonspecific sulfhydryl reduction in cells, obtained by supplementation of N-acetyl-L-cysteine (NAC) in a 0.1-10 mM concentration range. In human normal primary keratinocytes and in colon and ovary carcinoma cells we obtained evidences for: (i) a dose-dependent inhibition of proliferation without toxicity or apoptosis; (ii) a transition from a proliferative mesenchymal morphology to cell-specific differentiated structures; (iii) a noticeable increase in cell-cell and cell-substratum junctions; (iv) a relocation of the oncogenic beta-catenin at the cell-cell junctions; (v) inhibition of microtubules aggregation; (vi) upregulation of differentiation-related genes including p53, heat shock protein 27 gene, N-myc downstream-regulated gene 1, E-cadherin, and downregulation of cyclooxygenase-2; (vii) inhibition of c-Src tyrosine kinase. In conclusion, a thiol reduction devoid of toxicity as that operated by NAC apparently leads to terminal differentiation of normal and cancer cells through a pleiade of converging mechanisms, many of which are targets of the recently developed differentiation therapy. (literal)
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