http://www.cnr.it/ontology/cnr/individuo/prodotto/ID4439
Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms. (Articolo in rivista)
- Type
- Label
- Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms. (Articolo in rivista) (literal)
- Anno
- 2005-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/sj.cdd.4401663 (literal)
- Alternative label
T Parasassi (1); R Brunelli (1,2); L Bracci-Laudiero (1); G Greco (1); AC Gustafsson (3); EK Krasnowska (1); J Lundeberg (3); T Lundeberg (4); E Pittaluga (1); MC Romano (5); A Serafino (1) (2005)
Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms.
in Cell death and differentiation
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- T Parasassi (1); R Brunelli (1,2); L Bracci-Laudiero (1); G Greco (1); AC Gustafsson (3); EK Krasnowska (1); J Lundeberg (3); T Lundeberg (4); E Pittaluga (1); MC Romano (5); A Serafino (1) (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- PubMe (literal)
- Google Scholar (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- (1) Istituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 15-43, 00137 Roma, Italy;
(2) Dipartimento di Scienze Ginecologiche, Perinatologia e Puericultura, Universita' di Roma La Sapienza, Viale del Policlinico 155, Roma, Italy;
(3) Department of Biotechnology,KTH, Royal Institute of Technology, AlbaNova University Center, Roslagstullsbacken 21, Stockholm 10691 , Sweden;
(4) Rehabilitation Medicine, Karolinska University Hospital, Stockholm 11776, Sweden;
(5) Associazione Italiana Iniziativa Medicina Sociale, Corso Trieste 16, Roma 00185, Italy. (literal)
- Titolo
- Differentiation of normal and cancer cells induced by sulfhydryl reduction: biochemical and molecular mechanisms. (literal)
- Abstract
- We examined the morphological, biochemical and molecular outcome of a nonspecific sulfhydryl reduction in cells, obtained by supplementation of N-acetyl-L-cysteine (NAC) in a 0.1-10 mM concentration range. In human normal primary keratinocytes and in colon and ovary carcinoma cells we obtained evidences for: (i) a dose-dependent inhibition of proliferation without toxicity or apoptosis; (ii) a transition from a proliferative mesenchymal morphology to cell-specific differentiated structures; (iii) a noticeable increase in cell-cell and cell-substratum junctions; (iv) a relocation of the oncogenic beta-catenin at the cell-cell junctions; (v) inhibition of microtubules aggregation; (vi) upregulation of differentiation-related genes including p53, heat shock protein 27 gene, N-myc downstream-regulated gene 1, E-cadherin, and downregulation of cyclooxygenase-2; (vii) inhibition of c-Src tyrosine kinase. In conclusion, a thiol reduction devoid of toxicity as that operated by NAC apparently leads to terminal differentiation of normal and cancer cells through a pleiade of converging mechanisms, many of which are targets of the recently developed differentiation therapy. (literal)
- Prodotto di
- Autore CNR
- Insieme di parole chiave
Incoming links:
- Autore CNR di
- Prodotto
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
- Insieme di parole chiave di