Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Alternative label

• Pasquale Buanne a, Giuseppina Corrente a,Laura Micheli a,Antonella Palena b, Patrizia Lavia b, Corrado Spadafora c,Madepalli Krishnappa Lakshmana a,Alessandra Rinaldi d,Sandro Banfi e, Michæla Quarto e, Alessandro Bulfone e, Felice Tirone a, 1 (2000)
  Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium.
  in Genomics (S. Diego Calif.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pasquale Buanne a, Giuseppina Corrente a,Laura Micheli a,Antonella Palena b, Patrizia Lavia b, Corrado Spadafora c,Madepalli Krishnappa Lakshmana a,Alessandra Rinaldi d,Sandro Banfi e, Michæla Quarto e, Alessandro Bulfone e, Felice Tirone a, 1 (literal)

Pagina inizio

• 253 (literal)

Pagina fine

• 263 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 68 (literal)

Rivista

• Genomics (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• a Istituto di Neurobiologia, CNR, Viale Marx 43, 00137, Rome, Italy d Istituto di Tecnologie Biomediche, CNR, Viale Marx 43, 00137, Rome, Italy b Centro di Genetica Evoluzionistica, Via degli Apuli, 00100, Rome, Italy c Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy e Telethon Institute of Genetics and Medicine (TIGEM), Via Olgettina 58, 20132, Milan, Italy (literal)

Titolo

• Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium. (literal)

Abstract

• We identified in the EST database murine and human sequences similar, but not identical, to the members of the PC3/BTG/TOB family of cell cycle inhibitors. A conserved domain (aa 50-68) of the PC3 protein, the prototype member of the family, was used as a query. That domain has been shown by us to be necessary for the antiproliferative activity of PC3. A murine EST clone and a highly homologous human EST clone, containing the entire ORF, were chosen for sequencing. Comparison to databases and a phylogenetic tree analysis indicated that these EST clones are the mouse and human homologues of a gene that represents a novel member of the PC3/BTG/TOB family. This gene, named PC3B, is endowed with marked antiproliferative activity, being able to induce G1 arrest, and is highly expressed in testis, in oocyte, and in preimplantation embryos. Analysis of its expression during murine development indicated a specific localization in the olfactory epithelium at midgestation, suggesting that PC3B might be involved in the differentiation of this neuronal structure. Human PC3B mapped to chromosome 11q23, as indicated by radiation hybrid analysis. (literal)

Prodotto di

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Autore CNR

• PATRIZIA LAVIA (Persona)
• LAURA MICHELI (Unità di personale interno)
• FELICE TIRONE (Unità di personale interno)

Incoming links:

Autore CNR di

• FELICE TIRONE (Unità di personale interno)
• PATRIZIA LAVIA (Persona)
• LAURA MICHELI (Unità di personale interno)

Prodotto

• Istituto di neurobiologia e medicina molecolare (INMM) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Genomics (Rivista)