Biomimetic Mg- and Mg,CO3-substituted hydroxyapatites: synthesis characterization and in vitro behaviour (Articolo in rivista)

Type
Label
  • Biomimetic Mg- and Mg,CO3-substituted hydroxyapatites: synthesis characterization and in vitro behaviour (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.jeurceramsoc.2005.06.040 (literal)
Alternative label
  • Elena Landi; Anna Tampieri; Monica Mattioli-Belmonte; Giancarlo Celotti; Monica Sandri; Antonio Gigante; Paola Fava; Graziella Biagini (2006)
    Biomimetic Mg- and Mg,CO3-substituted hydroxyapatites: synthesis characterization and in vitro behaviour
    in Journal of the European Ceramic Society
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Elena Landi; Anna Tampieri; Monica Mattioli-Belmonte; Giancarlo Celotti; Monica Sandri; Antonio Gigante; Paola Fava; Graziella Biagini (literal)
Pagina inizio
  • 2593 (literal)
Pagina fine
  • 2601 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.sciencedirect.com/science/article/pii/S0955221905006680 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 26 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 13 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • ISTEC-CNR, Institute of Science and Technology for Ceramics--National Research Council, via Granarolo 64, 48018 Faenza (RA), Italy Istituto di Morfologia Umana Normale, Università Politecnica delle Marche, via Tronto 10/A, 60020 Ancona, Italy Dipartimento di Patologia Molecolare e Terapie Innovative, Università Politecnica delle Marche, via Tronto 10/A, 60020 Ancona, Italy (literal)
Titolo
  • Biomimetic Mg- and Mg,CO3-substituted hydroxyapatites: synthesis characterization and in vitro behaviour (literal)
Abstract
  • The doping of the apatite with carbonate or/and Mg ions in biologically-like amounts (6wt% and 1 wt%, respectively) was performed. Chemico-physical characterizations and cell culture tests were carried out onto the synthetic Mg-, Mg,CO3-substituted (~30-40 nm particle size) powders in comparison with stoichiometric HA (~160 nm particle size) to determine as mesenchymal stem cells (MSCs) can directly use the mineral microenvironment to stimulate their own proliferation and differentiation activities. At the same time the growth of human osteoblast like cells (MG-63) was evaluated to determine the compatibility of the synthetic doped apatites for bone substitution. Cell morphology analysis by SEM as well as MTT and ALP tests were performed. The peculiar chemico-physical properties of the doped (Mg-, Mg,CO3- substituted) materials improved the behaviours of MSC and MG-63 cells in term of adhesion, proliferation and metabolic activation compared to stoichometric HA. (literal)
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