http://www.cnr.it/ontology/cnr/individuo/prodotto/ID43286
Improvement in zirconia osseointegration by means of a biological glass coating: an in vitro and in vivo investigation (Articolo in rivista)
- Type
- Label
- Improvement in zirconia osseointegration by means of a biological glass coating: an in vitro and in vivo investigation (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
Nicoli-Aldini N., Fini M., Giavaresi G., Torricelli P., Martini L., Giardino R., Ravaglioli A., Krajewski A., Mazzocchi M., Dubini B., Ponzi Bossi M.G., Rustichelli F., Stanic V. (2002)
Improvement in zirconia osseointegration by means of a biological glass coating: an in vitro and in vivo investigation
in Journal of biomedical materials research (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Nicoli-Aldini N., Fini M., Giavaresi G., Torricelli P., Martini L., Giardino R., Ravaglioli A., Krajewski A., Mazzocchi M., Dubini B., Ponzi Bossi M.G., Rustichelli F., Stanic V. (literal)
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- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Improvement in zirconia osseointegration by means of a biological glass coating: an in vitro and in vivo investigation (literal)
- Abstract
- The biocompatibility and osseointegration of zirconia (ZrO2), either coated
with RKKP bioglazeĆ¢ or uncoated, were evaluated in vitro and in vivo. The
in vitro test was performed in human osteoblasts, whereas maximal
sensitization was performed in 23 Dunkin Hurtley guinea pigs. RKKP
bioglaze-coated and uncoated (controls) ZrO2 cylinders were implanted in
the distal femoral epiphyses of 14 Sprague Dawley rats under general
anaesthesia and animals were sacrificed at 30 and 60 days. Lactate
dehydrogenase, alkaline phosphatase, and Thiazolyl Blue (MTT) were tested
in vitro.
A graded score was used for evaluating the results of the sensitization
test. Histomorphometry and microhardness testing were performed to quantify
the osseointegration rate, as well as bone quality around the implants.
Neither in vitro cytotoxicity nor sensitization were observed.
Histomorphometry demonstrated that at 30 days, the affinity index was
significantly higher in coated implants than in uncoated ones (P<0.05); at
60 days, the behavior of coated implants was better than that of uncoated
ones, but differences were not significant. Significant increases in bone
microhardness were found at 1000 mm from the interface area for both
uncoated (p<0.0005) and RKKP bioglazeĆ¢-coated (p<0.0005) ZrO2, and also
within 200 mm from the interface (p=0.014) but only for coated ZrO2. These
results suggest that RKKP bioglaze-coated ZrO2 permits biocompatible
devices with improved osseointegration properties to be manufactured. (literal)
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